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Phospholipids
Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis
Liver fibrosis is a condition characterized by the accumulation of extracellular matrix (ECM) arising from the myofibroblastic transdifferentiation of hepatic stellate cells (HSCs) occurring as the natural response to liver damage. To date, no pharmacological treatments have been specifically…
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Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Abstract
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule,…
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Preparation and formula optimization of cephalexin loaded transferosomal gel by QbD to enhance the…
Most antibiotics used in topical formulations are not absorbed by deeper skin layers and subdermal tissues. Hence the skin infections are treated with large doses of oral or parenteral antibiotics which lead to unpleasant side effects with drug resistance. This could be the necessity for the…
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Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro,…
Tioconazole (TCZ) is a broad-spectrum fungicidal BCS class II drug with reported activity against Candida albicans, dermatophytes, and certain Staphylococci bacteria. We report the use of TCZ-loaded transethosomes (TEs) to overcome the skin’s barrier function. TCZ-loaded TEs were fabricated by using…
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Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective…
Oral intake of Itraconazole (ITZ) causes severe side effects in the gastrointestinal tract and has low bioavailability ~55%. Owing to these disadvantages, Transdermal drug delivery system (TDDS) of such antifungal agents can overcome such issues and can improve the efficacy and bioavailability. The…
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Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate
Sunburn is caused by prolonged exposure to ultraviolet (UV) rays from the sun, resulting in redness of the skin as well as tenderness, swelling, and blistering issues. During the healing process, it can cause peeling, irritation, and some long-term effects, including premature aging, pigmentation,…
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Formation and Investigation of Cell-Derived Nanovesicles as Potential Therapeutics Against Chronic…
Abstract
This study aims to offer a new therapeutic approach using cell-derived nanovesicles (cdNVs) to overcome the lack of effective treatments for liver fibrosis, a reversible chronic liver disease. To achieve this goal we established the formation and purification of cdNVs from untreated,…
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Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of…
Soybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid. Cremopher RH40 and caprylocaproyl macrogol-8 glycerides…
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Recent advances in oral drug delivery materials for targeted diagnosis or treatment of…
Abstract
Gastrointestinal diseases offer a serious potential hazard to people's health due to their high morbidity, mortality, and low early diagnosis rates. Due to its location within the body, the gastrointestinal tract is relatively difficult to observe and traditional endoscopy is primarily…
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Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and…
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising…
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