Sodium Starch Glycolate

Abstract Introduction Avanafil (AVA) is a very efficient phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. However, it has limited bioavailability when taken orally and considerable first-pass metabolism. Enhancing its solubility and choosing an alternative delivery…
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Purpose There are scarce reports on in vitro-in vivo correlation (IVIVC) model development of immediate-release (IR) formulations, and few investigations of the impacts of formulation and process of spray-dried solid dispersions (SDD)-based tablets on human pharmacokinetics (PK), despite commercial…
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Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This study aimed to enhance genistein’s solubility by developing solid dispersion (SD) and formulating them into tablets. The SDs were prepared using…
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Abstract Background/Objectives: Interest in 3D printing oral thin films (OTFs) has increased substantially. The challenge of 3D printing is film printability, which is strongly affected by the rheological properties of the ink and having suitable mechanical properties. This research assesses the…
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Introduction Super disintegrants are chemically modified version of traditional disintegrants used within tablets to improve the speed of release. The investigation looked at taking three commonly used super disintegrants (SSG, CCS and PVP) and incorporating into an Immediate release formulation.…
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Abstract Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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Abstract Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Abstract This study investigates the effects of disintegrants sodium starch glycolate (SSG) and crospovidone (CP) on the printability, rheological properties, and disintegration time of agar and hydroxypropyl methylcellulose (HPMC)-based formulations designed for semi-solid extrusion. Printability…
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Abstract Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts…
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Abstract Purpose Heart failure, a progressive cardiovascular disorder, significantly affects patient morbidity and mortality. Valsartan, an angiotensin II receptor antagonist, is widely used to mitigate the effects of heart failure, but its oral administration faces challenges such as poor…
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