Solubilizer

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is briefly reviewed. A systematic step-by-step approach is...

Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract Peptides are rarely orally administrated due...

Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the...

The potential for certain excipients to impact drug absorption is the subject of numerous publications. Reflecting this, current Biopharmaceutics Classification...

Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but not Female Rats It is known that males and females...

Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs....

The new e-Guide covers successful preclinical studies with Gattefossé excipients. Gattefossé developed a guideline to help formulate molecules with poor solubility...

As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively poor water solubility and permeation in vivo. In...

Multicomponent solid dispersions (MSD)s are frequently proposed as efficient drug delivery systems to improve drug solubility and bioavailability. In this...

This thesis has focused on the study of pharmaceutical cocrystal production, and the impact of introducing an excipient into the...