Poloxamer modified florfenicol instant microparticles for improved oral bioavailability

30. April 2020

Surfactants can improve the hydrophobicity of poorly water-soluble drugs and increase the stability of microparticles by reducing surface tension. This...

Enhanced dissolution and oral bioavailability of poorly water-soluble herb (Kaempferia parviflora) extract using solid dispersions: effect of surfactants and concentrations

29. April 2020

Kaempferia parviflora (KP) is a Thai traditional herb. The primary pharmacologically active substances are methoxyflavones, namely, 5,7-dimethoxyflavone, 5,7,4′-trimethoxyflavone, and 3,5,7,3′,4′-pentamethoxyflavone....

Common formulation strategies to improve API solubility for solid oral dosage forms

Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble active pharmaceutical ingredients

29. April 2020

Over the last twenty years, the poor solubility profile of pipeline drugs has limited their development as solid oral dosage...

Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment

11. April 2020

Leishmaniasis are a group of neglected infectious diseases caused by protozoa of the genus Leishmania with distinct presentations. The available leishmaniasis treatment...

Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral efficacy

30. March 2020

Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was...

Schematic representation of the different steps involved in the preparation of ASMP-Nano.

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

20. March 2020

The physiological protective mechanisms of the eye reduce the bioavailability of topically administered drugs above all for those with high...

Low temperature, easy scaling up method for development of smart nanostructure hybrid lipid capsules for drug delivery application

18. March 2020

Lipid Nanocapsules (LNCs) have been used for drug delivery in cells and animal models for several years. LNCs with unique...

Polyelectrolyte–surfactant–complex nanoparticles as a delivery platform for poorly soluble drugs: A case study of ibuprofen loaded cetylpyridinium-alginate system

11. March 2020

Previously, we reported on the surfactant cetylpyridinium chloride (CPC) as a crosslinker of alginate for the formation of stable polyelectrolyte–surfactant–complex...

Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant microspheres

10. March 2020

The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the...

The crucial effect of water and co-solvent on Liqui-Pellet pharmaceutical performance

10. March 2020

Liqui-Pellet is considered to be the next generation oral dosage form. It is highly commercially feasible unlike its predecessor, liquisolid...

Surfactants