Browsing Tag

polymers

Water-soluble and -insoluble polymers as binders for pellet preparation by extrusion/spheronization

Oct 31, 2018

The objective of this study was to investigate the effect of binder (water-soluble vs. -insoluble) and granulation fluid (aqueous vs. organic) on the physical properties of pellet prepared by extrusion/spheronization and on drug release. Size distribution, sphericity, bulk density, crushing force…
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Acrylic Polymers

Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution…

Oct 15, 2018

We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ), a poorly soluble drug, and its dissolution from spray-dried suspensions. To this end, ITZ suspensions with SSL, SL, and L grades of hydroxypropyl cellulose (HPC)…
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3D Printing

Additive Manufacturing with 3D Printing: Progress from Bench to Bedside

Sep 21, 2018

Three-dimensional (3D) printing was discovered in the 1980s, and many industries have embraced it, but the pharmaceutical industry is slow or reluctant to adopt it. Spiritam® is the first and only 3D-printed drug product approved by FDA in 2015. Since then, the FDA has not approved any 3D-printed…
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