Titanium Dioxide – TiO2

An industrial case study of attempting to comply with EU regulation 2022/63 Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has recently prohibited the application of this material in the…
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POTENTIAL TiO2 BAN STATUS AND IMPLICATIONS The EU considers banning TiO2 in pharmaceuticals, potentially impacting over 91,000 drug products and causing shortages. Titanium dioxide, also known as E171 or TiO2, has long been used across the cosmetics, medicine, and food industries without safety…
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The discussion about the excipient titanium dioxide in the European food industry is already several years old. TiO2 was banned from food products in the EU and other countries since 2022 as being maybe carcinogenic . This even had consequences for the pharmaceutical industry. Several suppliers now…
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The color of the tablets and capsules produced by pharmaceutical companies is important from the perspectives of product branding and counterfeiting. According to some studies, light can change tablet color during storage. In this study, tablets comprising amlodipine besylate (AB), a well-known…
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Background Though titanium dioxide (TiO2) is generally considered to have a low impact in the human body, the safety of TiO2 containing nanosized particles (NPs) has attracted attention. We found that the toxicity of silver NPs markedly varied depending on their particle size, as silver NPs with a…
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Titanium dioxide is extensively used in solid dosage forms as an opacifier and colorant. Due to regulatory developments and restrictions by authorities, formulators are increasingly interested in titanium dioxide-free solutions for both dietary supplements and medicinal products. Uniform colored and…
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Uniform colored and white coatings applied to tablets create a homogeneous appearance across batches, improving aesthetics and patient compliance. Titanium dioxide is used extensively in solid dosage forms for this purpose, serving as an opacifier and colorant. Due to its high refractive index, it…
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Judgment of the General Court in Joined Cases T-279/20, T-288/20 and T-283/20 | CWS Powder Coatings and Others v Commission First, the Commission made a manifest error in its assessment of the reliability and acceptability of the study on which the classification was based and, second, it…
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Film-coating agent formulated without TiO2, aluminium and artificial colors Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially in Europe. SEPIFILM™ NATurally COLored by Seppic are…
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Titanium dioxide is a ubiquitous white material found in a diverse range of products from foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has been considered no longer safe for use in foods (nano and microparticles of E171) by the European Food Safety Authority…
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