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Titanium Dioxide – TiO2
A weight of evidence review of the genotoxicity of titanium dioxide (TiO₂)
Titanium dioxide is a ubiquitous white material found in a diverse range of products from foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has been considered no longer safe for use in foods (nano and microparticles of E171) by the European Food Safety Authority…
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Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly…
Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to…
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EFSA, Bias, and Titanium Dioxide
EFSA cites a paper that lacks a vehicle control in addition to several papers with flawed study designs and inappropriate statistical analyses. All of this increases the risk of bias in EFSA's Opinion on E171 (Titanium Dioxide).
by Lyle Burgoon
When the European Food Safety Authority (EFSA)…
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Titanium dioxide (TiO2) as a food additive: Current science report from Canada
This notice from Health Canada on (Titanium Dioxide TiO2) as a food additive was published June 20, 2022. The current outcome in this notice is:
"In summary, the Food Directorate's position is that there is no conclusive scientific evidence that the food additive TiO2 is a concern for human…
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Lonza Expands its Capsugel® Capsule Offering to Include Titanium Dioxide-Free White Hard Gelatin…
Basel, Switzerland, 09 May 2022 – Lonza has expanded its Capsugel® offering with a titanium dioxide-free (TiO2-free) white hard gelatin capsule, fulfilling the evolving demand of its customers to meet new titanium dioxide-free requirements for foods in the European Union.
This novel opacifying…
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Titanium dioxide free film coating systems
European Food Safety Authority’s (EFSA) updated assessment on the safety of titanium dioxide as a food additive (published in summer 2021) concludes, that concerns about the genotoxicity of TiO2 particles cannot be excluded. As a result, the European Commission issued Commission Regulation (EU)…
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Potential Global Regulatory Impact of the EU E171 Ban on Dietary Supplements and Pharmaceuticals…
We have kept reporting on the latest TiO2 developments, from the 2019 ban in France, over the 2021 EFSA decision in food and feed, to our FAQ on TiO2.
To properly address this important topic, we decided to host a panel discussion on Titanium Dioxide at ExciPerience 2022. The experts Dr. Mahmud…
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Experts panel discussion on the future use of Titanium Dioxide (E171) in Pharma
We have kept reporting on the latest TiO2 developments, from the 2019 ban in France, over the 2021 EFSA decision in food and feed, to our FAQ on TiO2.
To properly address this important topic, we decided to host a panel discussion on Titanium Dioxide at ExciPerience 2022. The experts Dr. Mahmud…
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What’s next in the use of opacifiers for cosmetic coatings of solid dosage forms? Insights on…
The consolidated use of coatings containing E171 (i.e. titanium dioxide, TiO2) as an opacifier has made the white color of the resulting dosage forms a quality standard in the pharmaceutical and dietary supplement fields. This color is also associated with the efficiency of the coating layer in…
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JRS PHARMA Announces Launch of New TiO2-Free Tablet Coating VIVACOAT® free
Holzmühle, Germany | February 2022 - JRS PHARMA proudly introduces the solution for Titanium Dioxide free ready-to-use coatings, VIVACOAT® free.
In early 2022, Titanium Dioxide will be banned as a food additive in the EU, with additional regulations expected in other regions. Designed as a …
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