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Transdermal
Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Controlled release of amitriptyline via the transdermal route using SmartReservoirs and…
Abstract
SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This significantly improves the solubility of poorly soluble drugs, which…
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Assessment of leachables and extractables in “super-swelling” hydrogel-forming microarray patches
Abstract
Hydrogel-forming microarray patches (MAPs) offer a minimally invasive platform for transdermal drug delivery, enabling systemic absorption of active pharmaceutical ingredients. Unlike dissolving MAPs, which deposit their entire polymer matrix into the skin, hydrogel-forming MAPs remain…
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Inkjet printing of pharmaceutical tattoos for the direct deposition of oestradiol onto skin in…
Abstract
Turner syndrome, a rare chromosomal disorder affecting 1 in 2500 females, is characterized by the partial or complete absence of the second X chromosome. The primary treatment involves oestradiol (E2) hormone replacement therapy, essential for inducing puberty and maintaining secondary sex…
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Emerging for non-invasive heparin delivery systems: recent advances, barriers, solutions, and…
Abstract
Nowadays, the use of unfractionated low molecular weight heparins through intravenous and subcutaneous routes has been limited by several delivery challenges. These include pharmacological activity fluctuations, bleeding issues, and numerous manufacturing restrictions. To address these …
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Efficient transdermal drug delivery via a lance-microneedle delivery system with thumb force…
Abstract
To address incomplete drug release in monolithic dissolving microneedle (DMN) patches caused by non-selective drug dispersion into the backing layer, this study employs the lance-inspired architecture to develop a lance-microneedle (LMN) patch. The LMN patch features a decoupled microshaft…
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Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a…
Abstract
Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (CYC). Ethosomal vesicles prepared via the ethanol…
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Development of long-acting imidafenacin transdermal patches with high drug loading based on solid…
Abstract
Imidafenacin tablets are the first-line drug for the treatment of overactive bladder (OAB). However, the tablets need to be taken twice daily for up to 3–6 months, which highly reduces patient compliance. This study aimed to develop a long-acting imidafenacin transdermal patch (LAITP) with…
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QbD-Based Development of Fluocinolone Nanocomposite Transdermal Gel: Optimization, Characterization,…
Abstract
The current study presents a comprehensive pharmaceutical engineering approach to developing an advanced transdermal drug delivery system for addressing skin hyperpigmentation through innovative nanocomposite gel formulation. Utilizing a systematic Quality-by-Design (QbD) methodology with…
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Gangwal Healthcare – A solutions provider for Complex, Innovative & Cutting-edge…
Powered By Innovation, Driving Health, Wellness & Healing
The building of a “best in class” solutions provider starts with understanding the complexities of a customer’s need and identifying gaps. New technologies and Drug Delivery Systems are studied and appropriate excipients or raw-materials…
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