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Transdermal
Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However, when focusing on protein and peptide transdermal delivery,…
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Transdermal Administration of Nanobody Molecules using Hydrogel-Forming Microarray Patch Technology:…
Abstract
Nanobody molecules, derived from heavy-chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single-domain format facilitates the construction of multivalent molecules for therapeutic…
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Skin-friendly textures – by Gattefossé
Caring for patients
Patient preferences and needs as well as therapeutic indication should be considered at early stage of development of topical or transdermal formulations.
To increase adherence to skin treatments, it is important to consider patient’s needs, when designing the dosage…
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Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of…
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of…
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Leveraging novel innovative thermoresponsive polymers in microneedles for targeted intradermal…
Abstract
Microneedles have garnered considerable attention over the years as a versatile pharmaceutical platform that could be leveraged to deliver drugs into and across the skin. In the current work, poly (N-isopropylacrylamide) (PNIPAm) is synthesized and characterized as a novel material for the…
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Transdermal delivery and exploration of preclinical anti-rheumatoid efficacy of pirfenidone embedded…
To avoid adverse effects associated with non-site-specific delivery and target major signaling pathways responsible for the inflammation in rheumatoid arthritis, the current study aims to formulate and evaluate the transdermally administered potential of pirfenidone nanoemulgel in rheumatoid…
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Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery
A high-payload ascorbyl palmitate (AP) nanosuspension (NS) was designed to improve skin delivery following topical application. The AP-loaded NS systems were prepared using the bead-milling technique, and softly thickened into NS-loaded gel (NS-G) using hydrophilic polymers. The optimized NS-G…
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Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the…
Abstract
Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these…
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Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation
Abstract
Acyclovir (ACV) is an antiviral drug that is primarily used to treat herpes zoster virus (HSV) infections. HSV infections in deeper regions of the skin, i.e., nerve junctions, and appeared as a red spot on the upper part of the skin. The objective of the research is to formulate and…
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Preparation, optimization and evaluation of Osthole transdermal therapeutic system
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and…
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