Vaccines

This year, the 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology took place in Prague, Czech Republic. We show...

Abstract Ionizable aminolipids enable lipid nanoparticles (LNPs) to encapsulate nucleic acids at neutral pH and to release their cargo upon...

Abstract Since the first market authorization of RNA therapies, just eight years ago, the field has witnessed an extraordinary expansion,...

Highlights PLGA/PBAE coordinates endosomal escape and timely mRNA release in APCs PLGA/PBAE enhances mRNA transfection in APCs and promotes immune...

Abstract Cyclodextrins (CDs) have traditionally been recognized as excipients that enhance solubility and stability of drugs. However, growing evidence shows...

Abstract Hybrid lipid nanocapsules (hLNCs) represent a promising platform for mRNA delivery with the added benefit of ambient-temperature stabilization. Conventional...

Abstract mRNA delivered by microneedle patch (MNP) can enable painless delivery, reduced need for healthcare expertise, and improved thermostability. In...

Freeze-drying Technology in Pharmaceutical and Biomedical Product Development Freeze-drying Technology in Pharmaceutical and Biomedical Product Development See the new book,...

Abstract Lyophilization enhances mRNA vaccine stability, but conventional approaches using external trehalose for lipid nanoparticle (LNP) colloidal stability neglect mRNA...