Solid-state stability of advanced lipid-based excipients upon processing via extrusion and 3D-printing

See the poster by RCPE and IOI Oleo:

Lipids: Enormous potential impaired with tough challenges

This work investigates the solid-state stability of polyglycerol ester of fatty acids (PGFAs), as next generation lipid-based excipients (LBE), upon variation in their composition, different extrusion approaches, and when loaded with active pharmaceutical ingredient (API).

Composition tuning

• Tuning composition via increasing minor fractions in the system
• Enhanced filament’s mechanical properties for 3D-printing
• Controlled physicochemical properties required for drug release

Extrusion approaches

• Enhanced filament mechanical properties for 3D-printing
• Reduced filament porosity

API-loading

• API in molten lipid
• Feeding of molten mixture (liquid feeding)

Results

Possibility to overcome the challenges!

See the full poster on Solid-state stability of advanced lipid-based excipients upon processing via extrusion and 3D-printing here

(click the picture to download the poster)

Source: IOI Oleo, M.Abdelhamid, C. Corzo; M. Spoerk; C. Alva; E. Slama; T. Freichel; S. Reyer; D. Lochmann; S. Salar-Behzadi, Solid-state stability of advanced lipid-based excipients upon processing via extrusion and 3D-printing, RESEARCH CENTER PHARMACEUTICAL ENGINEERING, https://www.ioioleo.de/wp-content/uploads/A1_European_Meeting_2023_Poster_V3.pdf, https://www.ioioleo.de/en/cphi-pge/

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