Pentamidine isethionate, widely used for the treatment of parasitic infections, has shown strong anticancer activity in cancer cells and models of melanoma and lung cancer. Systemic administration of pentamidine is associated with serious toxicities, particularly renal, affecting as many as 95% of patients (O’Brien et al., 1997)…

http://www.ncbi.nlm.nih.gov/pubmed/25910415

Int J Pharm. 2015 Apr 21;488(1-2):154-164. doi: 10.1016/j.ijpharm.2015.04.060.