Binders play an important role in the tableting process of pharmaceuticals. They are used to improve the cohesion and plasticity of the powder mixture, which enhances the processability of the tablet and reduces the risk of tablet breakage during manufacture.
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Binder
Material-Sparing Feasibility Screening for Hot Melt Extrusion
Abstract
Hot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at determining the thermodynamic solubility and…
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Case Study PEARLITOL® 200 GT Mannitol: A Tool to Formulate Mini Tablets as a Compliant and Flexible…
PURPOSE
Mini tablets are a multiple unit dosage form with a size of less than 3.0 mm in diameter with great flexibility to deliver appropriate doses to the pediatric age group. They can be given in different numbers, according to dosage requirements, with no special prerequisite of formulating age…
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Minerals as Excipients – Dr. Paul Lohmann
The major component of ingredients in pharmaceutical products in terms of volume is not the active ingredient itself, it is the excipient. Excipients assist in the administration of an ‘active’ substance that typically may not be easily administered or absorbed by the patient.
Mineral Salts as…
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Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using…
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of…
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PVA as binder in continuous twin-screw granulation
Introduction
Granulation of powder blends is a commonly applied technique for pharmaceutical formulations which have no suitable flowability or compactability or are inhomogeneous with regards to the API content. Mainly wet granulation is applied3 and here, especially continuous twin-screw…
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VITAMIN E – Direct Compression with PROSOLV 730
Aim of the study
Solid dose formulations of Vitamin E, an oily active ingredient, are typically produced as soft-gel capsules in the pharmaceutical and nutraceutical industry. The manufacturing process of these soft-gel capsules is labor-intensive and costly. The goal of this study was to create…
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Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive…
Abstract
The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. The tableting machine was equipped with a thermally controlled die to mimic the heat…
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Roquette Introduced New Chapter in Moisture Protection at CPhI 2023
Press Release
La Madeleine (France), 25th October 2023 – Roquette, a global leader in plant-based ingredients and leading provider of pharmaceutical and nutraceutical excipients, is pleased to announce the addition of three new excipient grades to its unmatched portfolio of solutions for moisture…
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IFF and BASF collaborate on the Virtual Pharma Assistant Platform ZoomLab™
PRESS RELEASE
NEW YORK — Nov. 8, 2023 — IFF and BASF today announced a collaboration between the Pharma Solutions divisions of both companies, to onboard IFF’s leading product brands in pharmaceutical excipients into BASF’s Virtual Pharma Assistant platform – ZoomLab™. The platform is a…
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Study of Microcrystalline Cellulose as a Substitute of Magnesium Stearate Towards Functionality of…
Abstract
In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it decreases hardness of tablet in some formulations.…
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