Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

11. March 2022

Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis...

Fragment of the crystal structure of CTD-CAF, illustrating the channels formed by CTD molecules along the a-axis, in which pairs of CAF molecules are embedded.

Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

8. February 2022

A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which...

graphical abstract of Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution

Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution

17. January 2022

The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor...

Monitoring of high-load dose formulations based on co-processed and non co-processed excipients

10. September 2021

This work presents the evaluation of a co-processed material for high-load dose formulations and its real-time monitoring by near-infrared (NIR)...

graphical abstract of Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based Amorphous Solid Dispersions

Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based Amorphous Solid Dispersions

17. August 2021

For poorly soluble drugs formulated as amorphous solid dispersions (ASDs), fast and complete release with the generation of drug-rich colloidal...

Comparison of the CAD model with the printed outer surface of the 3D-printed tablets containing 20% NAP. (a) Distance map comparing the surfaces of the CAD model and the 3D-printed tablet (colours show the displacement between the CAD model and the printed tablet; grey shows the CAD model). (b) Distance map (cropped halfway) and CAD model surface in lower opacity (grey).

Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion

27. July 2021

Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded...

graphical abstract of High-Pressure Dielectric Studies—a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures

High-Pressure Dielectric Studies—a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures

20. July 2021

In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix...

Figure 5. Results from the non-sink, pH-shift microdissolution testing to assess the impact of various degrees of crystallinity on drug release and sustained supersaturation for samples at time zero and after stability storage at 25 °C/60% RH.

Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity

19. July 2021

We seek to further address the questions posed by Moseson et al. regarding whether any residual crystal level, size, or...

$Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach$

Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach

13. July 2021

The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of...

graphical abstract of The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

1. July 2021

In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX)...

Copovidone