Copovidone

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
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Abstract Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving…
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Abstract Additive manufacturing has been a breakthrough therapy for the pharmaceutical industry raising opportunities for long-quested properties, such as controlled drug-delivery. The aim of this study was to explore the geometrical capabilities of selective laser sintering (SLS) by creating…
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Abstract This study examines the influence of crospovidone (CP) manufacturer variability on the dissolution profiles of hydrochlorothiazide (HCTZ) tablets. Four CP batches from different manufacturers were characterized using pharmacopeial and physicochemical tests, including infrared absorption,…
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Abstract Amorphous solid dispersions (ASDs) are widely recognized for their potential to enhance the solubility of poorly water-soluble drugs, with factors such as molecular mobility, intermolecular interactions, and storage conditions playing critical roles in their performance. However, the…
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Abstract Enzalutamide (ENZ), marketed under the brand name Xtandi® as a soft capsule, is an androgen receptor signaling inhibitor drug actively used in clinical settings for treating prostate cancer. However, ENZ’s low solubility and bioavailability significantly hinder the achievement of optimal…
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Abstract This chapter reviews data on 72 omeprazole (OME) formulations developed in the past 5 years. The types of OME formulations, the excipients and the methods are analyzed in depth. Data on 72 omeprazole (OME) formulations created over the last 5 years are reviewed in this chapter. A…
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Abstract Currently, most amorphous solid dispersion (ASD) formulations contain a single polymer to stabilize an amorphous drug. However, a single polymer has a limited ability to form strong drug-polymer interactions, resulting in poor drug loading (<30 % w/w) and a high pill burden. This…
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Abstract This study leverages Fourier Transform Near-Infrared (FT-NIR) spectroscopy to monitor the coating process of pharmaceutical tablets using PVA-based TiO2-free films, with talc and iron oxides as opacifiers. By employing a combination of multivariate analytical techniques to evaluate the…
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Abstract Amorphous solid dispersion (ASD) tablets based on hydrophilic polymer carriers may encounter disintegration challenges. In this work, the effect of different formulation composition variables on the ASD tablet disintegration performance was systematically studied. GDC-0334: copovidone…
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