Ethylcellulose

Abstract Parkinson's disease is a debilitating neurodegenerative disorder that is primarily characterized by dopamine deficiency, which significantly impairs motor function and quality of life. Levodopa remains the gold standard treatment due to its efficacy in replenishing dopamine levels.…
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Abstract Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling the scarring process. SV exhibits great potential in treating various skin diseases owing to its antibacterial, antioxidant,…
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Abstract 3D printing offers a promising approach to creating personalized medicines. However, costly, expertise-dependent trial-and-error methods hinder efficient drug formulation, posing challenges for tailoring treatments to individual patients. To address this, a novel pipeline is developed for…
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Solidification of room temperature ionic liquids provides advantages in terms of handling and utilisation in the context of solid dosage forms. Encapsulating drug-based ionic liquids by direct spray operations represents a promising platform for solidifying and formulating these challenging…
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Abstract Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made of polyethylene glycol, polyvinyl caprolactam, and polyvinyl…
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Abstract Rheumatoid arthritis damages the synovial membrane, and diflunisal, a nonsteroidal anti-inflammatory drug (NSAID) with poor solubility, faces delivery challenges. Nanosponges enhance diflunisals solubility improving its bioavailability; in addition it improved its stability and controls…
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Abstract The type of plasticizer and the choice of solvent or co-solvents used for coating of a hydrophilic core can greatly impact the permeability, porosity, and mechanical strength of the polymer film. Although, Ethylcellulose (EC) is an old polymer, it is a polymer of choice for modifying the…
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Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the liver. The aim of this project was to enhance the systemic…
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Abstract Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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Abstract Oral medication administration is widely recognized as the most practical and widely used method. Medications with a short half-life and easy absorption in the gastrointestinal tract are quickly removed by the bloodstream. To avoid these issues, oral controlled-release formulations have…
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