Flavour / Flavor

Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently…
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Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward…
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Obtention of customized dosage forms is one of the main attractions of 3D printing in pharmaceuticals. In this sense, children are one of the groups within the population with a greater need for drug doses adapted to their requirements (age, weight, pathological state…), but most 3D printed oral…
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Sanhuang tablets (SHT) had a broad antibiotic spectrum with high efficiency and low toxicity. However, the clinical application was seriously limited by extremely bitter taste. A novel powder coating technology was established to mask the bitter taste of Sanhuang powder (SHP). Initially, the type…
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The major part (approx. 80%) of new drug actives are poorly soluble. Several techniques are used to enhance solubility including but lot limited to alternative salt forms, particle size reduction and solubility-enhancing excipients. Similar to APIs, many excipients are bitter or have other…
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Implication of Quantitative Selection of Each Excipient in Product Development Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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This article covers the different possibilities to characterize and quantify the sensory atttributes of APIs and drug products. Although in-vitro techniques such as e-tongues are available, sensory analysis is still the definitive method to identify and quantify taste masking challenges of APIs and…
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It is widely recognized that many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. But bitterness is not the only challenge in creating palatable, patient-accepted drug products. If not bitter, what are other common aversive sensory attributes? To answer this question, data…
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It is widely recognized that many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. But bitterness is not the only challenge in creating palatable, patient-accepted drug products. If not bitter, what are other common aversive sensory attributes? To answer this question, data…
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The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used…
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