Pharma Excipients
Glidant
Clean label ingredients for solid oral dosage forms
In general, clean label is a consumer driven movement, demanding a return to real food and transparency through authenticity. For nutritional supplements, this means that they should contain natural, familiar, simple ingredients that are easy to recognize, understand and pronounce.
Therefore, the…
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AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and parenteral drug products can reduce your project risk,…
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AEROSIL® Pharma colloidal silicon dioxide – technical information
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and parenteral drug products can reduce your project risk,…
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Material optimization for the development of delayed release formulation using computational tools
The present study involves designing a delayed-release tablet formulation of a drug belonging to BCS class-III further chemically classified as bisphosphonate to improve bioavailability. The typical approach to drug design experimentation calls for only one variable to be altered at a time, with all…
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Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on…
The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures (CPs) from 50 to 500 MPa was performed using a compaction…
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Sampling and diversion strategy for twin-screw granulation lines using batch statistical process…
Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects the complexity to translate a science that has been described in many publications to an actual drug product. Process stability…
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Design-of-experiment approach to quantify the effect of nano-sized silica on tableting properties of…
There are challenges to implementing high-speed direct compression tableting for poor flow, low-density cohesive powder. Thus, excipients with adequate flowability and bulk density are desired to facilitate this process. As a major novelty, the effect of nano-sized silica (Aerosil 200®) on the…
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100% visual inspection of tablets produced with continuous direct compression and coating
Visual appearance of tablets is an important property for patients. Since the visual appearance is most strongly influenced by the applied coating, this necessitates a high level of process control and homogeneity in the coating process. In recent years, a number of tablet coaters have been…
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See the new organic certified tableting premix from Biogrund – CompactCel® FLO Organic.
CompactCel FLO Organic helps to ensure a stable and consistent powder flow during the tableting and capsule filling process. Plus it reduces the interparticle friction.
CompactCel® FLO is a flow agent for loosening powder mixtures and improving flowability. The ready-to-use powder compound…
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Webinar: Stress-induced excipient function-switching: Neusilin transformation from glidant to binder…
Register now for the new & free webinar from Fuji Chemical Industries!
27th September 2021 - 10:00 AM CEST
Key discussions:
Neusilin behaviour
Free flowing powder
Acts as a glidant
Neusilin acts as a binder under compression
Under compression the granules deform in a…
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