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Lipid nanoparticles
Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown…
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Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug…
Abstract
Tocotrienols have higher medicinal value, with multiple sources of evidence showing their biological properties as antioxidant, anti-inflammatory, and osteoprotective compounds. However, tocotrienol bioavailability presents an ongoing challenge in its translation into viable products. This…
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Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Abstract
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule,…
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Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and…
Monoclonal antibodies (mAbs) hold promise for treating Parkinson's disease (PD), but their therapeutic use is hindered by poor delivery to the brain. In this study, we demonstrate that brain-targeted liposomes (BTL) enhance the delivery of mAbs across the blood-brain-barrier (BBB) and into neurons,…
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Propolis‑loaded nanostructured lipid carriers halt breast cancer progression through miRNA‑223…
Abstract
The most frequent malignant tumor in women is breast cancer, and its incidence has been rising every year. Propolis has been used for its antibacterial, antifungal, and anti-inflammatory properties. The present study aimed to examine the effect of the Egyptian Propolis Extract (ProE) and…
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Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient…
Objective
The primary objective of this study was to develop nanostructured lipid carriers of donepezil hydrochloride (DNZ HCl) for effective management of Alzheimer’s disease (AD).
Significance
Intranasal administration of DNZ NLC containing Nigella sativa (NS) oil as a liquid lipid may…
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Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine
Abstract
In recent decades, nanotechnology has been rapidly advancing in various fields of human activity, including veterinary medicine. The review presents up-to-date information on recent advancements in nanotechnology in the field and an overview of the types of nanoparticles used in veterinary…
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Nanocarriers mediated delivery of methotrexate is instrumental in treating auto-immune diseases and…
Methotrexate (MTX) is used extensively in cancer chemotherapy and for the management of various autoimmune disorders such as rheumatoid arthritis and psoriasis. The well reported mechanism of action of MTX is to obstruct the dihydrofolatereductase (DHFR) which inhibits the duplication of purines.…
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Design and development of lipid modified arginine based self-nanoemulsifying drug delivery systems…
Cefixime (CEF) has numerous potential applications in the treatment of bacterial infections. However, due to its decreased cellular internalization, poor aqueous solubility, rapid intestinal hepatic metabolism, its clinical efficacy is limited. The purpose of this research was to develop an…
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Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug…
Psoriasis with unclear etiology and pathogenesis is one of the most prevalent chronic skin diseases. It involves excessive keratinocytes cells hyperproliferation, abnormal vascular infiltration, and differentiation as its characteristic features. Patients need therapy on a periodic basis over a long…
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