Magnesium stearate, also known as magnesium octadecanoate, is a common additive used in the pharmaceutical industry. It is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
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Magnesium Stearate
Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel…
In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression…
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Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the…
(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets containing metronidazole (167 mg/g).
(2) Methods: The…
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Cleaning of Direct Compression Continuous Manufacturing Equipment through displacement of API…
Abstract
This feasibility study evaluates a cleaning process designed to avoid the use of detergents and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous manufacturing equipment was cleaned using excipients to displace ibuprofen residues from the system. The…
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CBD Oil Tablets Chewable – Direct Compression with PROSOLV 730
Aim of the Study
Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make directly compressible 25 mg CBD oil tablets as well as 25…
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Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
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Study of Compaction Tools and Parameters on Critical Quality Attributes of High Drug Load…
Minitablets are prepared using multiple die openings and multi–tip punches for greater productivity. With multiple tips on the punch barrel, the overall compaction force to be applied is commonly estimated by multiplying the desired compaction force per tip by the number of punch tips. Few…
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Discriminative Dissolution Method Development Through an aQbD Approach
Using a one-factor-at-a-time approach for dissolution method and discrimination analysis can be time-consuming and may not yield the optimal and discriminative method. To address this, we have developed a two-stage workflow for the dissolution method development followed by demonstration of…
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Effect of particle size on the dispersion behavior of magnesium stearate blended with…
The majority of tablets manufactured contain lubricants to reduce friction during ejection. However, especially for plastically deforming materials, e.g., microcrystalline cellulose (MCC), the internal addition of lubricants is known to reduce tablet tensile strength. This reduction is caused by the…
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Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating…
Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are versatile means for the highly efficient delivery of budesonide. However, uncontrolled agglomeration induces high deposition in the upper airway, causing local side effects due to high mechanical strength, worse…
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Influence of colloidal silicon dioxide‑magnesium stearate interaction on flow and compaction…
Abstract
The amount of glidant and lubricant in a tablet formulation is driven by their primary functionalities of enhancing flowability and reducing particle-wall friction. However, their interaction can lead to undesirable outcomes. This study has examined the influence of this interaction on…
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