Antisolvent Eudragit® polymers based in situ forming gel for periodontal controlled drug delivery

In situ forming gel (ISG) is relevant for periodontal pocket drug delivery because of its local administration with sustained drug release. Various types of 25% w/w Eudragit®-based ISG in different solvents were prepared for 5% w/w doxycycline hyclate (DH) loading. All Eudragit® types could be dissolved by N-methyl-2-pyrrolidone (NMP), and Eudragit® RL and RS are mostly dissolved in various types of solvent. Except for Eudragit® E, the 5% w/w DH-loaded Eudragit® solutions using NMP as the solvent transformed into gel state or matrix-like after exposure to phosphate buffer pH 6.8 and efficiently sustained a drug release. Eudragit® L ISG in NMP achieved a sustained drug release for longer than 7 days. Viscosity and injectability were increased as the concentration of Eudragit® L increased.

The 15%, 20% and 25% w/w Eudragit® L exhibited up to 52%, 48% and 42% drug released at 7 days. The drug release kinetic of DH-loaded in Eudragit® L mostly conformed with Higuchi’s kinetics with Fickian diffusion. Their degradation rate was decreased as Eudragit® L concentration increased meanwhile denser scaffolds structure was evident. In addition, Staphylococcus aureus, Escherichia coli, and the major pathogen of periodontitis, i.e., Porphyromonas gingivalis, were efficiently inhibited. Thus, DH-loaded Eudragit® L ISG using NMP as a solvent showed potential as the periodontal pocket delivery of DH for periodontitis treatment.

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Setthapong Senarat, Wiwat Pichayakorn, Thawatchai Phaechamud, Sarun Tuntarawongsa, Antisolvent Eudragit® polymers based in situ forming gel for periodontal controlled drug delivery, Journal of Drug Delivery Science and Technology, Volume 82, 2023, 104361, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2023.104361.

See also following article on Eudragit based Copolymer:

A Systematic Overview of Eudragit® Based Copolymer for Smart Healthcare