formulation

Hot Melt Extrusion (HME) technology was developed to obtain blends containing lyophilized Scutellariae baicalensis root extract and chitosan in order to improve the rheological properties of the obtained blends, including tableting and compressibility properties. (Hydroxypropyl)methyl cellulose…
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Oromucosal administration of zolmitriptan using electrospun nanofiber can potentially result in blood plasma concentrations analogous to intravenous kinetics and targeting the brain due to anatomical features of the delivery site. Herein, we report the optimization of zolmitriptan and…
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Monomeric globulins have been widely employed in food-grade nanoemulsion preparation owing to their outstanding emulsification performance. However, a limitation to stabilize nanoemulsions during storage exists when using monomeric globulin as sole emulsifier, mainly due to the low structural…
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Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the…
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Poster presented at 4th European Conference on Pharmaceutics 20-21 March 2023 | Marseille, France: Drug loaded pellets were produced by using the ProCell® lab system technology. The aim was to produce highly drug loaded matrix pellets with an API-polymer ratio of approximately 95:5 by using…
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To improve the solubility and maintain the amorphous state of BCS Ⅳ drug by preparing surfactant solid dispersions, solid dispersions of curcumin (CUR) with TPGS and HPMC were prepared by solvent method. The synthesized solid dispersions were characterized by scanning electron microscopy, powder…
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Introduction Controlled release dosage forms deliver an effective dose of the active pharmaceutical ingredient over a prolonged duration, which is particularly advantageous to maintain a constant plasma drug concentration within the therapeutic window. This effectively overcomes the negative…
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As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption…
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Mangiferin is a herbal drug that has proven anticancer potential. Owing to its lower aqueous solubility and poor oral bioavailability, the full pharmacological potential of this bioactive drug has not fully been explored. In the present study, phospholipid-based microemulsion systems were developed…
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Although mangiferin (MGN) is a natural antioxidant that could be a good candidate for the treatment of ocular diseases, its use in ophthalmology is strongly compromised due to its high lipophilicity. Its encapsulation in nanostructured lipid carriers (NLC) seems to be an interesting strategy for…
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