formulation

Introduction: Drug stability and shelf life are main targets of current pharmaceutical development as many active ingredients are highly moisture sensitive. Instead of using impermeable and expensive packaging materials it appears advisable to test moisture protective instant release film coatings.…
Read More...

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation…
Read More...

Lactose is the only FDA-approved carrier for dry powder inhaler (DPI) formulations in the US. Lactose carrier-based DPI products are contraindicated in patients with a known lactose allergy. Hence, inhaler formulations without lactose will benefit lactose allergic asthmatics.Objectives: to…
Read More...

In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a…
Read More...

Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for which a solid oral formulation was needed for further…
Read More...

Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in vivo oral bioavailability of poorly water-soluble drugs, however were only fabricated using a single lipid (LFCS type I formulations) and were not compared to their liquid precursors. This study…
Read More...

10 Errors that can occur during the coating process and how to avoid them Many parameters must be considered before and during the coating process. Sometimes it is necessary to adjust parameters to get the best possible result.See the troubleshooting guide as a video here:The…
Read More...

Top News of the weekNew vegetarian softgel system by Roquette Roquette launched LYCAGEL™ Market-first plant-based softgel system provides a strong alternative to gelatin for nutraceutical and pharmaceutical manufacturers and marketers of softgel products. Learn more here…
Read More...

Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they attract the attention of researchers in order to confront the challenge of poor water-solubility of orally given drugs. Within recent years, SEDDS were also discovered for oral administration of hydrophilic…
Read More...

Hemp products are mostly sold in liquid form. Companies who are trying to change this and offer solid dose products have to face different challenges.The challenges depend on their choice of solid dosage form (tablets or capsules), technical requirements, their marketing strategy (color, legal…
Read More...