Investigating the influence of the core formulation on the gastric resistant functionality of a solid oral dosage form coated with a Kollicoat® MAE 30 DP based coat
Developing a gastric resistant coating formulation can be quite demanding. There are a lot of interactions between polymer and active ingredient or non-functional excipients which have to be heeded. Even if all incompatibilities could be eliminated, the disintegration characteristics of the core might interfere with the coating functionality.
This work was set to investigate the influence of the core formulation on the functionality of the applied coat based on poly(methacrylic acid-co-ethyl acrylate) (MAE).
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