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      • CMC and Croscarmellose Sodium
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      • Modified Starch
      • Starch
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      • Glycols
      • Mineral Hydrocarbons
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      • Polyethylene Glycol (PEG)
      • Povidones
      • Propylene Glycol
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Startseite » News » MeltPrep – Rapid and Lossless Screening of Hot-melt Extruded Formulations

MeltPrep – Rapid and Lossless Screening of Hot-melt Extruded Formulations

6. June 2018
Hot-melt extrusion is well established in the plastics industry and is applied in pharmaceutical application for more than 30 years. In contrast to plastics, pharmaceutical formulation development is more complex as each formulation is unique in terms of compositions of active pharmaceutical ingredients, carrier and additives.

Therefore, new innovative solutions are demanded to tackle the pharma-specific challenges in formulation development like how to prevent losses with expensive material and how to handle sensitive materials formulations. Vacuum Compression Molding (VCM) by MeltPrep is a novel fusion-based screening method designed for those requirements. It mimics extrusion by melting a homogeneous micronized powder in an evacuated and adaptable sample chamber.

The chamber is formed by disposable foils and prototype tablets with defined geometries are obtained within minutes and without tedious cleaning. The implementation of VCM in the formulation development can lead to a lean formulation and process design. Less material and time and thus money is required to achieve development goals based on material understanding.

Watch the below video to MeltPrep: 

 

VCM Pharma Pro

Unlock the potential of a single researcher

Unleash the potential of individual researchers with the revolutionary VCM process that enables the generation of ASD or implant formulations in minutes, using only milligrams of material. Revolutionize formulation development with the tools to drive innovation in the field.

Formulation Development First

Develop at the speed of light.

Experience the key advantage of our streamlined approach, characterized by minimal process parameters and the elimination of extensive process development to obtain prototypes. Once the formulation is found, develop the process based on material data derived from VCM samples.

Prototyping your formulation in the mg-scale

Prepare a lossless prototype of any desired shape in less than 10 minutes. Only a few milligrams of your material are needed. Scale down to the µg range with the smallest size (0.3 mm).

 

Formulation without process development

The minimum amount of process parameters (melt temperature and time) allows you to quickly create your formulations without the pain of extensive process development.

 

 

 

Formulation Development First
Formulation Development First

Direct use for analysis

VCM geometries are designed to match relevant measurement techniques. Obtain accurate and reproducible results due to flawless and defined samples.

 

Speed up process development

Is your formulation working? Perform your process development efficiently and straightforwardly. Your tested formulation is ready for material characterization, enabling simulation & fast scale-up.

Sequential Parallelization

At least twice as fast.

The VCM sequential heating and cooling process allows the utilization of two VCM Tools. The cycle time is reduced by two. Thus, a single person can screen twice as many formulations. The VCM Pharma Pro will increase the tested formulations to 10 per hour.

Read more here

Source: MeltPrep, website MeltPrep


Read also the article:

Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations

Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations
Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations
Tags: excipientsformulation

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      • Converted Starch
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      • Modified Starch
      • Starch
      • Sugars
      • Sugar Alcohols
    • Petrochemicals
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      • Glycols
      • Mineral Hydrocarbons
      • Mineral Oils
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      • Pharmaceutical Oils
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      • Surfactants
      • Suspension Agent
      • Sustained Release Agent
      • Sweeteners
      • Taste Masking
      • Topical Excipient
      • Viscocity Agent
  • Sources
    • Handbook of Pharmaceutical Excipients – 9th Edition
    • EINECS Numbers
    • Excipient DMF List
    • Excipient cGMP Certification Organisations
    • FDA Inactive Ingredient List
    • FDA GRAS Substances (SCOGS) Database
    • Excipient E-Numbers
    • Whitepapers / Publications
    • Contract Development|Contract Manufacturing
  • Suppliers
    • A-B
      • ADM
      • ARMOR PHARMA
      • Ceolus™ & Celphere™
      • Ashland
      • BASF
      • Beneo – galenIQ
      • Biogrund
      • Budenheim
    • C-G
      • Captisol
      • Croda
      • Cyclolab
      • DFE Pharma
      • DuPont Pharma Solutions
      • Evonik
      • Fuji Chemical Industries
      • Gattefossé
      • Gangwal Healthcare
    • I-O
      • ingredientpharm
      • IOI Oleochemical
      • JRS Pharma
      • Kerry
      • KLK Oleo Life Science
      • Lactalis Ingredients Pharma
      • Lipoid
      • Dr. Paul Lohmann
      • Lubrizol
      • Magnesia
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      • Roquette Pharma
      • Seppic
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      • Sigachi Group
      • Südzucker AG
      • VIKRAM THERMO
      • Zerion Pharma
      • ZoomLab® – Your Virtual Pharma Assistant
  • Inquiries
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    • Tailored Tableting Excipients
      • Tailored Film Coating
  • Events
    • Overview Pharmaceutical Webinars
    • Videos CPhI Frankfurt 2025
    • CPhI China 2024
    • ExciPerience – The great excipient event!
  • All4Nutra

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