Sex-Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

2. November 2022

Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex-related differences cannot be...

What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships

2. November 2022

The discovery of carcinogenic nitrosamine impurities above the safe limits in pharmaceuticals has led to an urgent need to develop...

Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the dissolution profile in conventional mini-USP II and a biorelevant colon model

2. November 2022

The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the...

Effect of a superdisintegrant on disintegration of orally disintegrating tablets determined by simulated wetting test and in vitro disintegration test

1. November 2022

Abstract The disintegration time is critical for characterizing orally disintegrating tablets (ODTs), according to regulatory standards. The current study aimed...

Roquette-New-Direct-Compression-Solutions

CPHI 2022: Roquette Launches Next-Generation Direct Compression Solutions – PEARLITOL® CR-H Mannitol and PEARLITOL® 200 GT Mannitol

1. November 2022

La Madeleine, France – October 31, 2022. Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical...

Why Oral Disintegrating Tablets - by Roquette

Oral Disintegrating Tablets – see the solution landscape

1. November 2022

Introduction Oral disintegrating tablets (ODTs) are patient-centric drug delivery systems (for example, for pediatrics, geriatrics, and psychiatric patients with dysphagia)...

Ashland injectable pharmaceutical excipient accepted into FDA Novel Excipient Review Pilot Program

1. November 2022

WILMINGTON, Del., Oct. 31, 2022 -- Ashland Inc. (NYSE: ASH) today announced the United States Food and Drug Administration (FDA)...

Construction of Bio-conjugated nano-vesicles using non-ionic surfactants for targeted drug delivery: A computational supported experimental study

31. October 2022

Introduction Targeted delivery of drugs to the brain is a complicated activity. This complication is caused by the blood–brain barrier...

Microfluidic Particle Engineering of Hydrophobic Drug with Eudragit E100─Bridging the Amorphous and Crystalline Gap

31. October 2022

Co-processing active pharmaceutical ingredients (APIs) with excipients is a promising particle engineering technique to improve the API physical properties, which...

Neusilin® the extraordinary excipient for solid dosage forms – Technical Newsletter

31. October 2022

See the third issue of Fuji Chemical Industries Technical Newsletter. This issue focuses on achieving higher tablet hardness with pleasant...

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