Analysis of phospholipids and triacylglycerols in intravenous lipid emulsions

27. October 2022

Intravenous lipid emulsions (ILEs) are used for parenteral nutrition, providing a vital source of essential fatty acids and concentrated energy for patients who are unable to...

Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

27. October 2022

With the advent of continuous manufacturing, twin-screw melt granulation has attracted interest in the pharmaceutical industry as a method for...

Physical stability of co-freeze-dried powders made from NaCl and maltodextrins – Impact of NaCl on glass transition temperature, water vapour sorption isotherm and water vapour sorption kinetics

26. October 2022

NaCl is commonly added into food powders as a humectant or taste enhancer with little consideration of its impact on...

Patient-specific in vitro drug release testing coupled with in silico PBPK modeling to forecast the in vivo performance of oral extended-release levodopa formulations in Parkinson’s disease patients

26. October 2022

Biorelevant in vitro release models are valuable analytical tools for oral drug development but often tailored to gastrointestinal conditions in ‘average’ healthy...

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

26. October 2022

Abstract Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in...

Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra

26. October 2022

Abstract Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of...

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability

25. October 2022

The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such...

Industry Perspective on the Use and Characterization of Polysorbates for Biopharmaceutical Products Part 2: Survey Report on Control Strategy Preparing for the Future

25. October 2022

Abstract Polysorbate (PS) 20 and 80 are the main surfactants used to stabilize biopharmaceutical products. Industry practices on various aspects...

A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

25. October 2022

In rotary tablet presses, the powder flow into the dies is typically facilitated by paddle feeder. For internally lubricated formulations,...

Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

25. October 2022

Drug delivery systems (DDS) for oral delivery of peptide drugs contain excipients that facilitate and enhance absorption. However, little knowledge exists on...

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