A combination formulation of TPGS micelles loaded with paclitaxel and olaparib and a pH-thermosensitive hydrogel for treating peritoneal metastasis and drug-resistant ovarian cancer
Abstract
Purpose
Ovarian cancer (OC) is difficult to detect early; therefore, it is highly likely to advance to peritoneal metastasis at the time of diagnosis. Moreover, multi-drug resistance (MDR) results in a high recurrence rate. To address these issues, the present study aimed to design an intraperitoneally administered formulation…