Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications

Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications. Commercially, SBE-β-CD is popular by its brand name Captisol®. The present review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs).


• Sulfobutylether-β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide.

• SBE-β-CD is used to improve the solubility, and stability of small molecules.

• It lessens the volatility, irritation, and hides smell or taste of small molecules.

• Present review is the state-of-the-art collection on SBE-β-CD.

SBE-β-CD is an emerging functional biopolymer for drug delivery.

Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD.

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Chandrakantsing V. Pardeshi, Rucha V. Kothawade, Ashwini R. Markad, Sagar R. Pardeshi, Abhijeet D. Kulkarni, Prashant J. Chaudhari, Marcela R. Longhi, Namdev Dhas, Jitendra B. Naik, Sanjay J. Surana, Monica C. Garcia, Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications, Carbohydrate Polymers, 2022, 120347, ISSN 0144-8617,

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