New generation of supramolecular mixtures: Characterization and solubilization studies

In this work, a series of novel low melting mixtures (LMM) based on cyclodextrins (CD) and levulinic acid and inspired by the deep eutectic solvents (DES), were prepared. These supramolecular mixtures are the first reported CD-based mixtures that are liquid at room temperature. Density, viscosity and rheological measurements as well as differential scanning calorimetry and thermogravimetric analysis were performed to characterize these new LMM. Nuclear magnetic resonance (NMR) spectroscopy was used to monitor their stability.

Furthermore, their ability to solubilize trans-anethole (AN) and related essentials oils were evaluated by static headspace-gas chromatography (SH-GC), in comparison with water. AN was up to 1300 times more soluble in the CD-based LMM than in water. Finally, multiple headspace extraction (MHE) was used to monitor the release of AN from these LMM. After 10 extractions, 20 to 40% of AN was released from the studied LMM, while 70% was released from water. The new CD-based LMM have potential applications for solubilization and delivery of poorly soluble drugs.

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Article Information: Author links open overlay panelTracy El Achkar, Leila Moura, Tarek Moufawad, Steven Ruellan, Somenath Panda, Stéphane Longuemart, François-Xavier Legrand, Margarida Costa Gomes, David Landy, Hélène Greige-Gerges, Sophie Fourmenti; International Journal of Pharmaceutics, 2020.

Keywords: Cyclodextrins, Static headspace-gas chromatography, Trans-anethole, Essential oils, Low melting mixtures.

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