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Ocular Delivery
Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: A novel approach for…
High intraocular pressure (IOP) is the main risk factor for glaucoma progression. Acetazolamide (AZM) presents a potent IOP-lowering effect but is only administered orally due to its low aqueous solubility and ocular permeability. This study aimed to develop AZM nanocrystals (AZM-NC) as an…
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Efficient liposomal encapsulation and intraocular diffusion of astaxanthin in a topical ophthalmic…
Abstract
This study evaluates the encapsulation efficiency and intraocular diffusion of astaxanthin-loaded liposomes for ophthalmic topical delivery. Liposomes were prepared using self-forming method and subjected to physicochemical and microscopic characterizations, achieving over 98%…
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Development and evaluation of ocular antibiotic-loaded soluble film inserts
Abstract
Antibiotic eyedrops typically require frequent instillation due to the eye’s defensive mechanisms limiting drugs from reaching target sites. This may risk patient non-adherence and treatment inefficacy. The aim of this study was to develop a biocompatible and fully soluble ocular film…
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Innovative formulations for the ocular delivery of coenzyme Q10
Abstract
Coenzyme Q10 (CoQ10) is a lipophilic antioxidant agent that plays a crucial role in the mitochondrial electron transport chain. The neuroprotective role of CoQ10, countering mitochondrial dysfunction and oxidative stress, suggests its potential as an adjuvant for ocular…
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Mucoadhesive gellan gum/poly(2-ethyl-2-oxazoline) films for ocular delivery of pilocarpine…
Abstract
The study aims to develop new prolonged delivery systems of pilocarpine hydrochloride (pilocarpine⸱HCl) for the therapy of glaucoma. Polymer films based on gellan gum (GG) and its mixtures with poly(2-ethyl-2-oxazoline) (POZ) at different ratios were prepared by casting. The films were…
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Development of a Temperature and pH Dual-Sensitive In-Situ Gel for Treating Allergic Conjunctivitis
The purpose of this study was to improve the efficacy of olopatadine hydrochloride (OT) in treating allergic conjunctivitis (AC). To achieve this goal, we developed an eye formulation without antimicrobial agents using a temperature-pH dual-sensitive in situ gel technology combined with heat…
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Enhanced Ocular Drug Delivery of Dexamethasone Using Chitosan-Coated Soluplus® Based Mixed Micellar…
Abstract
Background: This study introduces a novel dexamethasone (DEX) mixed micellar system (DEX-MM) using Soluplus® and Pluronic F-127 (PF127) to enhance ocular drug delivery. The enhancement of ocular application properties was achieved by creating a chitosan-coated DEX-MM (DEX-CMM), which…
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Imaging-Based Drug Penetration Profiling in an Excised Sheep Cornea Model
Abstract
Formulations designed to address ocular conditions and diseases are predominantly administered topically. While in vitro test systems have been developed to assess corneal permeation under extended contact conditions, methods focusing on determining the penetration depth and kinetics of a…
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Recent advances in modified chitosan-based drug delivery systems for transmucosal applications: A…
Abstract
Recently, transmucosal drug delivery systems (TDDSs) have been extensively studied because they protect therapeutic agents from degradation; improve drug residence time at the mucosal membranes; and facilitate sustained drug release for a prolonged period. Chitosan is a well-researched…
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Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular…
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections, etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes mellitus, thyroid, rheumatic disorders, and others. Chitosan (CS) and its derivatives have been widely investigated…
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