Pharma Excipients
Cellulose Ethers
Oral raft forming in situ gelling system for site specific delivery of calcium
In situ gelling Raft forming system (GRFS), a novel sol-gel system of calcium carbonate (CC) was developed with the aim to prolong the gastric residence time and thereby the bioavailability. A simple lattice mixture design was adopted to study the effect of formulation composition (% HPMC K100 M and…
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Role of Polymer Physicochemical Properties on in vitro Mucoadhesion
Polymers with mucoadhesive properties are universally used in the development of mucoadhesive drug delivery system. Their physicochemical properties as well as the mechanisms related to their adhesive actions draw great attention for the modification of mucoadhesive properties.
In this study,…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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Development of arsenic trioxide sustained-release pellets for reducing toxicity and improving…
Arsenic trioxide (ATO) is first-line drug for acute promyelocytic leukemia. Clinically, the continuously slow intravenous infusion is adopted to maintain effective blood concentration and reduce toxic effects, but it causes poor patient' compliance for a considerable infusion period. To overcome…
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Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
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Comparison between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol
Nebivolol (NBH) is a third-generation β1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low…
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Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired…
The objective of this work was to develop taste-masked donut-shaped tablet formulations utilizing fused filament fabrication three-dimensional printing paired with hot-melt extrusion techniques. Caffeine citrate was used as the model drug for its bitter taste, and a 3-point bend test was performed…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Novel high-drug-loaded amorphous dispersion tablets of posaconazole
Amorphous solid dispersions (ASDs) can increase bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and therefore large dosage-form size or multiple units to meet dose requirements,…
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Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
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