HPMC - Hydroxypropylmethylcellulose

Maintaining the long-term stability of Oral Solid Dosage Form (OSDF) is a multi-dimensional challenge, primarily dictated by a formulation's stability...

Abstract The aim of this study was to develop a once-daily controlled-release (CR) apixaban (APX) formulation that enhances bioavailability through...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Abstract Poor solubility of curcumin (Cur) has greatly limited its applications. To establish Cur amorphous solid dispersions (Cur ASDs) with...

Abstract Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine...

Abstract Low water solubility and extensive hepatic first-pass metabolism limit oral bioavailability of Nebivolol hydrochloride (NEB), a new-generation β-blocker agent...

Abstract Hydroxypropyl methylcellulose (HPMC) is commonly used to enable controlled release (CR) of an active pharmaceutical ingredient (API) from a...

Abstract We report gastroretentive (GR) tablets optimized via a data-driven regression-based predictive modeling strategy to determine the optimal hydroxypropyl methylcellulose...

Abstract Background/Objectives: This study aims to investigate the underexplored impact of capsule type on the performances of capsule-based dry powder...

Abstract Poor aqueous solubility and thereby poor and/or variable bioavailability of drug candidates is frequently overcome by developing enabling formulations...