Poloxamer

Abstract Background: Poloxamers are promising biomaterials for drug delivery applications due to their ability to enhance biopharmaceutical properties. Methods: This study focused...

Abstract Delamanid, an antituberculosis drug used for multidrug-resistant tuberculosis, has extremely poor water solubility and a high melting point of...

Abstract This study explores the impact of drug loading (DL) on the physical stability, dissolution performance, and micellisation behaviour of...

Abstract Background/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study...

Abstract Stabilization of therapeutic protein formulations with nonionic surfactants such as Polysorbate 20 (PS20), Polysorbate 80 (PS80), or Poloxamer 188...

Abstract Hospital pharmacies are not equipped to produce lipid nanoemulsions, which are generally obtained using high-energy processes. This study reports...

Abstract Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility...

Abstract The development of safer treatment alternatives for cancer and other chronic illnesses still calls for innovation. Chemopreventive agents (e.g.,...

This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly...

This study explores the role of 2-hydroxypropyl-β-cyclodextrin (HPβCD) as an excipient in liquid formulations by evaluating its physical properties, thermal...