Poloxamer

Abstract Background/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study...

Abstract Stabilization of therapeutic protein formulations with nonionic surfactants such as Polysorbate 20 (PS20), Polysorbate 80 (PS80), or Poloxamer 188...

Abstract Hospital pharmacies are not equipped to produce lipid nanoemulsions, which are generally obtained using high-energy processes. This study reports...

Abstract Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility...

Abstract The development of safer treatment alternatives for cancer and other chronic illnesses still calls for innovation. Chemopreventive agents (e.g.,...

This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly...

This study explores the role of 2-hydroxypropyl-β-cyclodextrin (HPβCD) as an excipient in liquid formulations by evaluating its physical properties, thermal...

Abstract Lipid-based drug delivery carriers have exhibited substantial potential for promoting wound healing. Here, Phospholipon® 90H (P90H) based lipid nanoparticles...

Abstract The limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability,...

Abstract Topical dosage forms represent a critical segment of pharmaceutical products, offering localized drug delivery with minimal systemic exposure. This...