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Silicon Dioxide
Enhanced stability of levodopa and benserazide fixed-dose combination tablets through optimized…
Abstract
Parkinson's disease is a debilitating neurodegenerative disorder that is primarily characterized by dopamine deficiency, which significantly impairs motor function and quality of life. Levodopa remains the gold standard treatment due to its efficacy in replenishing dopamine levels.…
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Deep learning-based image classification and quantification models for tablet sticking
Abstract
Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level co-occurrence matrix (GLCM) based…
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Effect of additives and operating conditions on tablet weight variation: Analysis based on powder…
Abstract
The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and…
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Quantification of Antibiotics in Multicomponent Drug Formulations using UV-Vis Spectrometer with PLS…
Abstract
This study explores the potential of spectroscopic analysis combined with Partial Least Squares Regression (PLS) and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) for the simultaneous quantification of antibiotics in multicomponent drug formulations, specifically…
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3D printing personalized orally disintegrating tablets with complex structures for the treatment of…
Abstract
Individuals with special needs, such as children, the elderly, and the visually impaired, encounter significant hurdles in the field of personalized pharmacotherapy due to their distinctive medication needs. 3D printing technology, a novel approach for preparing drug products with…
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Development of tablet formulations containing genistein solid dispersion optimized using Box-Behnken…
Abstract
Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This study aimed to enhance genistein’s solubility by developing solid dispersion (SD) and formulating them into tablets. The SDs were prepared using…
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Co-Processing Acetaminophen with Nanocellulose to Enhance Tabletability
Abstract
Nanocellulose, a sub-micron cellulose powder, was investigated as a potential filler excipient to enhance the tabletability of acetaminophen (APAP). Due to its high specific surface area, nanocellulose was expected to outperform the tabletability enhancement provided by microcrystalline…
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Advances in Taste-Masking Strategies for Pediatric Brain-Related Disease Treatments: Focus on…
Abstract
Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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The impact of glidants on the rheological properties of active pharmaceutical ingredients: A study…
Abstract
Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing…
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Advanced Oral Breviscapine Sustained-Release Tablets for Improved Ischemic Stroke Treatment
Abstract
This study aimed to address the challenges associated with the low oral bioavailability and the necessity for frequent dosing of breviscapine (BRE), a mainstream drug in the treatment of cardiovascular and cerebrovascular diseases. The poor solubility and permeability of BRE in the…
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