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Silicon Dioxide
Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage…
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In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In…
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Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of…
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Segregation of Formulated Powders in Direct Compression Process and Evaluations by Small Bench-Scale…
Powder segregation can cause severe issues in processes of pharmaceutical drugs for control of content uniformity if the powder is likely to be free or easy flowing. Assessing segregation intensity of formulated powders in a process is challenging at the formulation stage because of the limited…
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Transform Liquid-form Active Ingredient into Powder form with High Performance Liquid Carrier
Introduction
Several major active ingredients for human health, such as vitamin A/D/E/K, DHA/EPA, and natural herbal
extracts are supplied in liquid form. Emulsified powder and microencapsulation were previously known as the
major ways to provide better compatibility with other ingredients, but…
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Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery…
Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the…
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Investigation of Various Polymers for SLS 3D-Printing of Solid Oral Dosage Forms
Purpose
Selective laser sintering (SLS) is promising for printing oral dosage forms.
Print ranges for commonly used pharmaceutical polymers not yet established for additive manufactured medications.
Evaluate dedicated polymers for pharmaceutical applications.
Objectives…
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Study of Powder and Tableting Functionality Towards Evaluation and Characterisation of BARETab® PH…
Abstract
BARETab® PH is a multi-functional ready to use premixed, co-processed ingredient for direct compression (DC) formulations. It is a combination of selective, largely used excipients for DC. Direct compression is the most widely used tableting method because of the simple manufacturing…
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Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil…
The aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to…
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Tableting of liquid form active ingredient with high performance liquid carrier
1. Introduction
Many liquid active ingredients are supplied in a soft-gel capsule form, because a soft gel capsule is easy to release control and can avoid formulation difficulties. However, it has serious weakness in stability, especially in humid environments; swallowability in the elder people,…
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