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Skin delivery
Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin…
Skin carcinoma remains one of the most widespread forms of cancer, and its global impact continues to increase. Basal cell carcinoma, melanoma, and squamous cell carcinoma are three kinds of cutaneous carcinomas depending upon occurrence and severity. The invasive nature of skin cancer, the limited…
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Development and Evaluation of Docetaxel-Loaded Nanostructured Lipid Carriers for Skin Cancer Therapy
This study focuses on the design, characterization, and optimization of nanostructured lipid carriers (NLCs) loaded with docetaxel for the treatment of skin cancer. Employing a systematic formulation development process guided by Design of Experiments (DoE) principles, key parameters such as…
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Alternatives to Conventional Topical Dosage Forms for Targeted Skin Penetration of Diclofenac Sodium
Skin penetration of an active pharmaceutical ingredient is key to developing topical drugs. This penetration can be adjusted for greater efficacy and/or safety through the selection of dosage form. Two emerging dosage forms, cream–gel and gel-in-oil emulsion, were tested for their ability to deliver…
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Fungal Infections: Effect of Eudragit RL-100 Based Miconazole Film Forming Spray
ABSTRACT
Background: Miconazole nitrate, a BCS class II drug which is used for treatment of fungal infections. To minimize the disadvantages of sticky creams and ointments and their tendency to rub off, an intelligent dosage regimen needs to be designed as a film-forming spray formulation. The…
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Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug…
Abstract
Ketoprofen is a non-steroidal, anti-inflammatory drug frequently incorporated in topical dosage forms which are an interesting alternatives for oral formulations. However, due to the physiological barrier function of skin, topical formulations may require some approaches to improve drug…
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Improvement of lidocaine skin permeation by using passive and active enhancer methods
Lidocaine is generally recognized and preferred for local anaesthesia, but in addition, studies have described additional benefits of lidocaine in cancer therapy, inflammation reduction, and wound healing. These properties contribute to its increasing importance in dermatological applications, and…
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Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to…
Parkinson's disease (PD), affecting about ten million people globally, presents a significant health challenge. Rotigotine (RTG), a dopamine agonist, is currently administered as a transdermal patch (Neupro®) for PD treatment, but the daily application can be burdensome and cause skin irritation.…
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Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically administered orally or intramuscularly. Transdermal drug delivery…
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Towards the Development of a Cream with Antiviral Properties Targeting Both the Influenza A Virus…
Abstract
Objective: Many severe acute respiratory infections are caused by viral pathogens, and viruses are responsible for a large number of deaths worldwide. Among the most common respiratory viruses are the influenza A virus (IAV) and, more recently, the SARS-CoV-2 that emerged in 2019 and…
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In vitro evaluation of microneedle strength: a comparison of test configurations and experimental…
Abstract
To ensure the safe and effective application of microneedles for drug delivery to the skin, the mechanical properties the microneedles and their ability to penetrate the skin are critical quality control parameters. While ex vivo and in vivo evaluations may be valuable to demonstrate…
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