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Skin delivery
Fabrication of porous polymeric microneedles: A concise overview
Abstract
Recent advancements in microneedle (MN) technology have increasingly focused on porous polymeric microneedles (PPMNs), which are, among various types of MN, emerging as a promising platform for diverse biomedical applications, including transdermal drug delivery, interstitial fluid (ISF)…
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Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a…
Abstract
Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (CYC). Ethosomal vesicles prepared via the ethanol…
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A drug delivery perspective on nanotechnology-based topical therapeutics for inflammatory skin…
Abstract
Inflammatory skin diseases are chronic conditions that significantly affect patients’ skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe…
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Ethyl-Cellulose Nanosponges for Topical Delivery of Simvastatin with Preferential Skin Retention for…
Abstract
Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling the scarring process. SV exhibits great potential in treating various skin diseases owing to its antibacterial, antioxidant,…
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Understanding the Structure-Release Relationships of Sepineo™: molecular dynamics, physico-chemical…
Abstract
The physical and mechanical characteristics of gels are crucial in developing and manufacturing various topical therapeutic products. This study thoroughly examined the influence of pH modifications and the ionization status of diclofenac sodium, as an Active Pharmaceutical Ingredient…
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Electrospun Nanofiber-Scaffold-Loaded Levocetirizine Dihydrochloride Cerosomes for Combined…
Abstract
Objectives: In this study, we aimed to incorporate levocetirizine dihydrochloride (LVC) into electrospun nanovesicle-in-nanofiber (NF) scaffolds for combined management of atopic dermatitis and methicillin-resistant Staphylococcus Aureus skin infection, to sustain LVC release for…
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Nanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment…
Abstract
Background: Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach…
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Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia…
Abstract
Background: Alopecia areata is an autoimmune disorder that causes hair loss in clumps about the size and shape of a quarter. The estimated prevalence of the disorder is approximately 1 in 1000 people, with a lifetime risk of approximately 2 percent. One of the systemic therapies for…
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QbD-Based Development of Fluocinolone Nanocomposite Transdermal Gel: Optimization, Characterization,…
Abstract
The current study presents a comprehensive pharmaceutical engineering approach to developing an advanced transdermal drug delivery system for addressing skin hyperpigmentation through innovative nanocomposite gel formulation. Utilizing a systematic Quality-by-Design (QbD) methodology with…
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Multilayer gradient chitosan fiber scaffolds for skin tissue regeneration with enhanced mechanical…
Abstract
Using the solution blow spinning technique, a trilayer structure scaffold was developed for skin tissue engineering. The scaffold, composed of chitosan/polyethylene oxide (CHI/PEO) fibers, mimicking the skin's natural structure, featuring a fiber diameter gradient ranging from 300 to 1200 …
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