Skin delivery

Abstract Hyperlipidemia and its associated cardiovascular complications are the major causes of mortality and disability worldwide. Simvastatin (SIM) is one of the most commonly prescribed lipid-lowering drugs for the treatment of hyperlipidemia by competitive inhibition of…
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Abstract Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, in stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® …
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Abstract The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and…
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For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug…
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The story of ivermectin originated in 1974, when scientist Satoshi Omura discovered Streptomyces avermitilis, which later led to the isolation of an active compound, avermectin and finally, ivermectin . Ivermectin, which consists of two homologs (namely dihydro-avermectin B1b and dihydro-avermectin…
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Abstract As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by…
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PRODUCT INFORMATION HyPearls® combine exfoliation and hydration in one step. Incorporated in high quality cosmetic products, HyPearls® function as a scrubbing agent, replacing micro plastics. In a second step, Hyaluronic acid is released for optimized skin hydration. This content of Hyaluronic Acid…
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Following topical application of a dermatological product, the loss (by evaporation and/or absorption through the skin) of volatile excipients will alter the composition of the formulation remaining on the tissue. This so-called metamorphosis impacts the concentration of the drug in the residual…
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Recent developments in materials science have spurred remarkable progress in the field of microneedle technology, offering novel approaches to address key challenges in drug delivery, biosensing, and other biomedical applications. This preview examines three innovative concepts inspired by recent…
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Guanfacine (GFC) extended-release tablet (Intuniv®) is an effective non-stimulant medication prescribed for attention deficit hyperactivity disorder (ADHD), presenting limitations regarding patient compliance and safety risks. The study aimed to design a novel long-acting transdermal delivery system…
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