Solubility Enhancement

Abstract This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low…
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The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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Abstract Purpose The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems (THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac diethylamine (DDEA), a non-steroidal anti-inflammatory drug. The research question focuses on whether THEDES…
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We invite you to our next webinar: "Rational Selection of Cyclodextrins for the Solubilization of Poorly Soluble Oral Drugs" Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Formulation in a complex with…
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Overview of the article The Importance of API Solubility for Solid and Liquid Dosage Forms The Solubilization Process The Biopharmaceutics Classification System of APIs The Developability Classification System The Central Role of Solubility and Permeability for API Absorption…
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Abstract The incorporation of phloretin (PHL), a dihydrochalcone flavonoid, in functional foods is usually hampered by its low aqueous solubility. In this regard, we investigated the impact of complexation of PHL with sulfobutylether-β-cyclodextrin (SBE-β-CD, Captisol®) to overcome its limitation.…
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Raloxifene (RLX) is popularly indicated in treatment of osteoporosis and prevention of breast cancer. Owing to its poor aqueous solubility, high pre-systemic metabolism, intestinal glucuronidation, and P-glycoprotein (P-gp) efflux, however, it demonstrates low (< 2%) and inconsistent oral…
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Various approaches have been developed to enhance the solubility or dissolution rate for the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility sensitivity analysis for oral absorption, a comparative assessment of the biopharmaceutical performance of a…
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Drug solubilization studies are continuously being conducted. Febuxostat (FBX) has a low solubility in water. This study aims to develop a stable FBX-solid dispersion (SD) formulation using a solvent evaporation method. The solubilization strategy of FBX is to develope an optimal FBX-SD formulation…
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1. Introduction Solid dispersion is one of the most effective technologies to improve API characteristics such as solubility, stability, and compressibility. Recently developed small molecule APIs with the aim to higher therapeutic effects, tend to become poor soluble, as much as 70% or higher…
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