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Startseite » Solubility Enhancement
Summary Background: Pharmaceutical excipients have traditionally been regarded as inactive components of dosage forms. However, in bioenabling formulations, they are...
Abstract Low water solubility and extensive hepatic first-pass metabolism limit oral bioavailability of Nebivolol hydrochloride (NEB), a new-generation β-blocker agent...
Abstract Alectinib (ALB) is a kinase inhibitor typically used for patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer....
This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly...
Abstract Polymeric micelles are promising nanocarriers for improving the solubility and therapeutic efficacy of poorly water-soluble drugs. In this study,...
Abstract The limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability,...
Lipid excipients offer a unique combination of benefits Poor solubility, poor permeability, and pre-systemic elimination are factors that can...
Abstract Background/Objectives: Dihydroquercetin (DHQ), also known as taxifolin, is a natural flavonoid which has anti-inflammatory and wound-healing biological effects. One...
Abstract Lipid-based formulations (LBFs) play a crucial role in enhancing the oral bioavailability of poorly water-soluble drugs by leveraging lipid...
Abstract Manufacturing co-processed pharmaceutical excipients is a great innovation in drug delivery, with improved compressibility, flowability, disintegration, and reduced moisture...
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