Solubility Enhancement

Abstract Objective CACN136 is a novel curcumin analogue with antidepressant potential, but its poor aqueous solubility may restrict oral absorption....

Abstract Curcumin has considerable therapeutic potential; however, its poor solubility and permeability limit its clinical applications. We evaluated menthol-based hydrophobic...

Abstract Cyclodextrins (CDs) are cyclic oligosaccharides made up of α-(1 → 4)-linked d-glucopyranose units and are generally obtained by enzymatic conversion of...

Abstract Porous silicates have been investigated as drug carriers to promote the solubility and in vitro dissolution of poorly water-soluble...

Abstract This study presents a Quality by Design (QbD) strategy combined with Design of Experiments (DoE) to develop hybrid polymer–lipid hot-melt extruded (HME) formulations...

Abstract Background A dihydrofolate reductase inhibitor, pyrimethamine has an emerging anticancer potential but is not well soluble in aqueous and...

Regulatory support for New Approach Methodologies is growing rapidly. For excipients, however, acceptance remains largely case-specific and linked to the...

Abstract Hesperetin (HSP), a naturally occurring citrus flavanone with diverse antioxidant, anti-inflammatory, and pharmacological activities, has attracted considerable attention as...

Abstract Purpose Azithromycin, a macrolide antibiotic, exhibits dissolution-limited oral absorption due to its poor solubility, and that affects its therapeutic...

Abstract Aim Efonidipine hydrochloride ethanolate (EHE), a BCS Class II calcium channel blocker, exhibits extremely poor aqueous solubility and undergoes...