Solubility Enhancement

In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during conventional processing. The production of pellets by…
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Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier and coating materials respectively. Varying the carrier to…
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This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion (ASD) system development by profiling the excipients’ capability to solubilise, amorphisise, and stabilise the chosen active…
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Salt chemistry is pretty complicated, and one of the more abstract concepts to understand is pHmax! Here, Pharma Drama looks at what pHmax is and what changes a salt will undergo on either side of it. This knowledge is super-useful when understanding salt stability! So even though the concept is a…
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The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In…
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A week ago I wrote about the importance of new and novel excipients for the pharmaceutical industry and presented Klucel™ xtend and BioSustane™ in last week´s edition of "The Excipients Week". In the meantime I launched a small poll with the title "Was there innovation in excipients over the last…
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The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast HPLC method was developed to quantify enalapril maleate and…
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An explanatory video by Prof. Simon Gaisford – Pharma Drama Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going to explain the concept of ideal solubility – so if that sounds ideal, get yourself a drink and then…
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Many orally administrated drugs exhibit poor bioavailability due to their limited solubility. The smartFilm technology is an innovative approach to improve the drug aqueous solubility, where the drug is embedded within the matrix of cellulose-based paper in an amorphous state, hence increasing its…
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Pea protein isolate (PPI)-maltodextrin (MD) conjugates were prepared by using controlled Maillard reaction at 90 °C in the solution state (wet-heating route). The degree of conjugation between PPI and MD was measured in terms of evolved colour, UV absorbance, and molecular weight change. Results…
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