Solubility Enhancement

Abstract Aim Efonidipine hydrochloride ethanolate (EHE), a BCS Class II calcium channel blocker, exhibits extremely poor aqueous solubility and undergoes...

Abstract Poor aqueous solubility is a major cause of solubility-limited absorption and misleading pharmacokinetic outcomes during early oral drug discovery....

Abstract The oral delivery of biologics such as oligonucleotides may be enabled by the use of a chemical permeation enhancer...

Abstract Despite various attempts at solubility enhancement and advances in formulation technologies, improving the bioavailability of poorly water-soluble compounds remains...

IOI Oleo launched a new family of functional, lipid-based excipients, the polyglycerol esters at CPhI 2025. As the CPhI 2026...

Abstract Aceclofenac (ACF) is a commonly used non-steroidal anti-inflammatory drugs (NSAID) for numerous inflammatory conditions; however, its therapeutic potential is...

See in the following the PhD research poster by Abdelazeez Mohamednour 1-Aim and Context of Work Amorphous solid dispersions enhance...

Abstract The beneficial effect of bedaquiline fumarate (BQF) for tuberculosis (TB) is limited by its oral bioavailability, which is very...

Abstract Purpose Simvastatin (SIM) is a widely prescribed lipid-lowering agent; however, its clinical efficacy is hindered by poor aqueous solubility...

AI in pharmaceutical drug product design is, in 2026, a decision-support technology, not autonomous formulation. The most mature tools combine...