Solubility Enhancement

Abstract The beneficial effect of bedaquiline fumarate (BQF) for tuberculosis (TB) is limited by its oral bioavailability, which is very...

Abstract Purpose Simvastatin (SIM) is a widely prescribed lipid-lowering agent; however, its clinical efficacy is hindered by poor aqueous solubility...

AI in pharmaceutical drug product design is, in 2026, a decision-support technology, not autonomous formulation. The most mature tools combine...

Abstract Background Diosgenin (DG) is a steroidal sapogenin derived from medicinal plants such as Dioscorea nipponica, Smilax china, and Trigonella foenum-graecum. DG exhibits...

Abstract Objectives: Tolvaptan is a compound that is practically insoluble in water and poorly soluble at physiological pH, and is...

Abstract Cannabidiol (CBD) is a non-psychoactive compound derived from Cannabis sativa. It has attracted significant attention for its anti-inflammatory, pain-relieving, and...

Abstract In this research, with the aim of improving the solubility and bioavailability of famotidine, the inclusion complex of famotidine...

Abstract Background: Rebamipide (REB) is a poorly water-soluble drug with limited ocular bioavailability, necessitating advanced delivery strategies for sustained therapy in...

Abstract Purpose Cabazitaxel (CBZ) is a semi-synthetic anti-cancer drug and belongs to BCS class IV category with poor water solubility...

Abstract This study aimed to develop strategies to prevent accelerated drug release (alcohol-induced dose dumping) from modified-release matrix tablets in...