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Solubility Enhancement
Importance of β-cyclodextrin substitution level and type for solubilization and stabilization of…
This poster was presented at CRS 2024 in Bologna
Introduction
Parenteral formulations often contain higher concentrations of excipients than active ingredients. These excipients enhance safety, provide solubility, better stability, increase bioavailability, improve patient compliance, or generally…
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SOLBIOTE (TM)- Bringing Sustainable Solutions to Biopharmaceuticals
SOLBIOTE (TM) – Injectable-grade Saccharide Excipients for Biopharmaceuticals
Nagase Viita, the first company in the world to mass produce Trehalose, has launched a new product brand SOLBIOTE (TM). This brand features high-purity, low-endotoxin Trehalose (TREHALOSE SG) and Maltose (MALTOSE PH)…
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Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of…
Berberine is used in the treatment of metabolic syndrome and its low solubility and very poor oral bioavailability of berberine was one of the primary hurdles for its market approval. This study aimed to improve the solubility and bioavailability of berberine by preparing pellet formulations…
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Transformative solidification techniques for self-emulsifying drug delivery and its foresight in…
Abstract
Self-emulsifying drug delivery systems (SEDDSs) represent a significant breakthrough in addressing bioavailability
challenges by enhancing the solubilization of poorly water-soluble drugs, ensuring consistent formulation properties,
and facilitating easy industrial scale-up. Despite…
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Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and…
Abstract
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems. In particular, the introduction of drug delivery systems is a potential approach to enhance…
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3D printed scaffolds as delivery devices for nanocrystals: A proof of concept loading Atorvastatin…
Abstract
Increasing the solubility of drugs is a recurrent objective of pharmaceutical research, and one of the most widespread strategies today is the formulation of nanocrystals (NCs). Beyond the many advantages of formulating NCs, their incorporation into solid dosage forms remains a challenge…
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Nucleotides as new co-formers in co-amorphous systems: Enhanced dissolution rate, water solubility…
Abstract
Developing co-amorphous systems is an attractive strategy to improve the dissolution rate of poorly water-soluble drugs. Various co-formers have been investigated. However, previous studies revealed that it is a challenge to develop satisfied acidic co-formers, e.g., acidic amino acids…
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Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug…
Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic metabolism. The aim of this study was to explore the potential of employing Hot Melt Extrusion (HME) technology for the continuous production of Self…
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Comparison of two self-nanoemulsifying drug delivery systems using different solidification…
In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid self-nanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its…
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Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut stability and solubility remain challenges to be addressed in the healthcare industry. Herein, we fabricated and…
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