Solubility Enhancement

Introduction to Micro environmental pH-Modulated Dissolution Micro environmental pH-modulated dissolution describes an approach in controlled oral drug delivery where the...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Abstract Poor solubility of curcumin (Cur) has greatly limited its applications. To establish Cur amorphous solid dispersions (Cur ASDs) with...

Abstract Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility...

Overview of Functional Core Use in Drug Delivery A tartaric acid starter core for extended release formulations serves as a functional nucleus...

Summary Background: Pharmaceutical excipients have traditionally been regarded as inactive components of dosage forms. However, in bioenabling formulations, they are...

Abstract Low water solubility and extensive hepatic first-pass metabolism limit oral bioavailability of Nebivolol hydrochloride (NEB), a new-generation β-blocker agent...

Abstract Alectinib (ALB) is a kinase inhibitor typically used for patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer....

This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly...

Abstract Polymeric micelles are promising nanocarriers for improving the solubility and therapeutic efficacy of poorly water-soluble drugs. In this study,...