Solution

Lipid-based formulations (LbFs) have demonstrated success in pharmaceutical applications; however, challenges persist in dissolving entire doses of the drug into defined liquid volumes. In this study, the temperature-induced supersaturation method was employed in LbF to address drug loading and pill…
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Abstract A novel polymer synthesized by grafting three cyclodextrins onto chitosan was characterized and evaluated for its potential to adsorb two pharmaceutical residues: ibuprofen and progesterone. The influence of various operational parameters, including contact time, initial molecule…
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Hot melt extrudates with combinations of Soluplus® and Aqoat® AS-L or Eudragit® EPO were investigated to improve drug release and to overcome the pH-dependent release of poorly water-soluble basic (itraconazole, ITZ) and acidic (mefenamic acid, MFA) drugs. The release of ITZ was improved in both 0.1…
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Abstract The liquisolid system of drug delivery continues to find usefulness as a potent means to circumvent solubility and dissolution challenges commonly encountered during drug formulation and medicine development in the pharmaceutical industry. Originally invented by Spireas, the technique has…
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Gelatin, a versatile protein derived from animal sources, is crucial in producing softgel capsules. Known for its ability to form gels in aqueous solutions, gelatin provides the perfect medium for encapsulating various substances. This comprehensive guide will explore the different aspects of…
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Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
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The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR)…
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Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types of fills for softgel capsules: Single Oil or Oil Mixtures,…
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Abstract Purpose This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy. Methods Tween® 80 and Soluplus® were evaluated to enhance the water solubility of IVM powder. Three dissolving MAPs were fabricated using…
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Nagase Viita Co., Ltd. (Headquarters: Shimoishii, Kita-ku, Okayama; Representative Director: Naoki Yasuba), a member of the NAGASE Group, has launched a new product brand, SOLBIOTETM, featuring their saccharide-based pharmaceutical excipients of high-purity and low-endotoxin TREHALOSE SG and MALTOSE…
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