Sorbitol

Three-dimensional (3D) printing is a potential technique for developing personalized medicines. Among its applications, mold manufacturing in industrial 3D printing stands out, especially for creating complex structures. This capability has been innovatively extended to drug development. Our study…
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INTRODUCTION Soft capsules are a popular dosage form for dispensing active pharmaceutical or nutraceutical materials. The shell material is frequently composed of gelatin, softened with considerable amount of plasticizer. They are especially adapted for liquids and for the formulation of hardly…
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Abstract The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly for neonates. Toxicity and efficacy divergences have been…
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Introduction & Aim Media for cell culture has evolved from recipes containing plant or animal-derived products, to fully chemically defined (CD) formulations as an effort to reduce variability in bioprocess performance due to raw materials. A critical ingredient, poloxamer 188, has a history…
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Purpose Hot melt extrusion (HME) is a pivotal pharmaceutical manufacturing process employed to enhance the bioavailability of poorly soluble active pharmaceutical ingredients (APIs) in oral dosage forms. Often the applicability of the process is limited by the melt viscosity. The upper limit is…
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The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of…
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Abstract Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and dissolution rates of poorly soluble drugs when employed as carriers in solid dispersions (SDs). However, synthetic polymers dominate the preparation…
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Introduction Additive manufacturing or 3D printing technology refers to the fabrication of three-dimensional objects from computer-aided designs (CAD) by adding layers of material on top of each other successively. In oral pharmacotherapy, this technology presents a paradigm shift from the current…
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Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions such as temperature changes, pH changes, or agitation. Similar stresses are applied to proteins during downstream purification. Shifts in pH during Protein A…
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Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the…
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