Formulation and Quality Control Test for Fast- Dispersible Aspirin Tablets

Abstract

The goal of this study was to create and evaluate dispersible aspirin tablets in order to increase patient compliance, especially for those who have difficulty swallowing regular pills. Aspirin, a widely used analgesic and anti-inflammatory medicine, frequently causes stomach discomfort in its standard form. Dispersible pills have the potential to improve stomach tolerance and have a quicker onset of action. To achieve rapid dispersion in water, relevant excipients such as Disintegrants, binders, and diluents were added to the direct compression method utilised in the tablet and wet granulation procedures. The physicochemical characteristics of the produced tablets, such as weight variation, hardness, friability, disintegration time, and homogeneous drug content, were assessed. After optimization, the tablet characteristics exhibited promising results, releasing more than 85% of the drug after 30 minutes and dispersing in less than 3 minutes.  There may be quicker absorption and therapeutic benefits as a result of this rapid disintegration and dissolving profile. Expedited stability testing found no noticeable modifications in the tablet’s chemical and physical features throughout a three-month period. Dispersible aspirin tablets are a potential dose form that provide a practical and efficient substitute for conventional aspirin tablets, according to the study’s findings. This formulation strategy may help increase patient compliance, especially in the case of elderly and paediatric patients, as well as those who have swallowing issues.

Introduction

Capsules and tablets are the most used solid dosage forms. Yet, many individuals have serious swallowing problems. Drinking water helps facilitate the swallowing of oral dosage forms. Traditional dosage forms, tablets are often difficult for people to swallow when they are dehydrated, experiencing motion sickness, or suddenly developing a cold, allergies, or bronchitis. Due to these characteristics, tablets that dissolve or disintegrate rapidly in the oral cavity have attracted a lot of interest.1-3 A solid dosage form that dissolves fast on the tongue usually in a few seconds is called an oral dispersible tablet. The term “oral dispersible tablet” was introduced by the European pharmacopoeia to describe these dosage forms and highlight their significance. The term describes a tablet that can be taken orally and quickly dissolves before being swallowed.4

A highly specialised method called drug delivery system (DDS) is used to deliver pharmaceutical chemicals throughout the body in order to provide specific therapeutic effects. In order to ensure that the right amount of medication is delivered in the appropriate location and time within the body, these systems are essential to modern medicine. This approach is crucial for minimizing side effects, maximizing drug efficacy, and improving patient outcomes.5 DDS is essential for improving a medication’s therapeutic index. By regulating the medication release’s rate, time, and place, these systems can significantly improve both pharmacokinetics (the movement of drugs within the body) and pharmacodynamics (the effects of drugs on the body). For instance, traditional oral or injectable formulations may lead to fluctuating drug levels in the bloodstream, which can reduce efficacy and increase side effects. However, advanced DDS can provide sustained and controlled release of the drug, maintaining optimal therapeutic levels over extended periods and minimizing the need for frequent dosing. 6

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Materials and Methods

For the formulation and assessment experiments, the following chemicals and tools were employed.

Table 1: List of Materials

Duraisamy U, Mohan K, Kamaraj A. S, Jayasankar S, Poomalai T, Ezhilarasan V. Formulation and Quality Control Test for Fast- Dispersible Aspirin Tablets. Biomed Pharmacol J 2025;18(4). Available from: https://bit.ly/48m1AWX

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