Pharma Excipients
Speciality Excipient
Pharma-MMC, Pharmaceutical grade Mesoporous Magnesium Carbonate
Pharma-MMC is a proprietary drug delivery technology for amorphous stabilization and solubility enhancement of drug substances and for unique drug formulations - addressing unmet industry needs:
High drug-load (up to 50% w/w)
Long term amorphous stability of poorly soluble drugs (>12…
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Resins That Allow Distinctive Drug Delivery Solutions – POLYOX™ product information
POLYOX™ resins are nonionic poly (ethylene oxide) polymers. They are white to off-white, free-flowing hydrophilic powders supplied in a wide variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. POLYOX™ polymers possess thermoplastic…
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Developments in encapsulation of insulin: Is oral delivery now possible?
This review presents the possibilities of oral delivery of insulin.
Insulin, being readily destroyed/transformed by the proteolytic enzymes and first-pass effects in the digestive system, has mainly been administered through injection, such as intravenous injection and transdermal injection. With…
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Solidifying ticagrelor loaded self-microemulsifying drug delivery system
The aim of this study was to solidify a ticagrelor loaded self-microemulsifying drug delivery system (TCG-SM) with enhanced dissolution and bioavailability of ticagrelor (TCG) for developing TCG-SM granules and tablets.
TCG was dissolved in the self-microemulsifying drug delivery system (SMEDDS)…
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Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and…
The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility. Furthermore, new chemical entities are even less soluble compared to marketed…
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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying…
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Thermoplastic polyurethane as matrix forming excipient using direct and ultrasound-assisted…
Thermoplastic polyurethanes (TPU) are block copolymers utilized in a wide variety of applications due to their superior characteristics as resistance, flexibility and biocompatibility. However, the use of TPU as a matrix tablet forming excipient is more limited.
For the first time, matrix tablets…
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Shedding light on interaction of so called inactive ingredients (excipients) with…
Permeability glycoprotein (P-gp) is a 170 kDa membrane transporter from the category of efflux pumps, which is situated at the apical site of epithelial membrane. P-gp is known to efflux diverse classes of chemical compounds including anticancer agents, antibiotics, steroidal compounds and many…
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Biodegradable polymers for modern vaccine development
Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy.
This review summarizes the potential of…
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Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for…
The aims of this study were to prepare hydrogenated soybean phosphatidylcholine (HSPC) matrices by hot melt extrusion and to evaluate resulting matrix potential to extend drug release in regard to drug loading and solubility for oral drug delivery of water-soluble drugs.
The liquid crystalline…
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