Pharma Excipients
Speciality Excipient
Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary…
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried…
Read More...
Read More...
Amorphous pullulan trehalose microparticle platform for respiratory delivery
Spray drying biologics and small-molecule drugs can increase their thermal stability relative to liquid dosage forms and allow for widespread distribution to developing countries without cold chain infrastructure. In this study, pullulan trehalose powder is spray dried for inhalation.
The powder…
Read More...
Read More...
Polymer degradation induced drug precipitation in PLGA implants – Why less is sometimes more
Nifedipine and nicardipine loaded PLGA extrudates have a great potential to prevent cerebral vasospasms after subarachnoid hemorrhage or surgical clipping of aneurysm. A constant release over approx. two weeks is desired. Although in vivo studies on humans have been reported, there is limited…
Read More...
Read More...
Mucus penetrating properties of soft, distensible lipid nanocapsules
Designing nanomaterials to release their drug pay-load upon exposure to an exogenous trigger can help to direct drug delivery, but how the triggered release, which often modifies the nanomaterial properties, influences the biological fate of these systems is currently unknown. The aim of this study…
Read More...
Read More...
Oral delivery of insulin via mesoporous carbon nanoparticles
In this article, a new type of mesoporous carbon nanoparticles (MCN) was fabricated as a potential oral delivery system of insulin to reduce the adverse reactions by hypodermic injection. The mesoporous carbon nanoparticles-carried insulin (MCNI) was studied using scanning electron microscopy (SEM),…
Read More...
Read More...
Mucoadhesive approach for buccal application: Preactivated chitosan
Buccal adhesive drug delivery has gained pharmaceutical interest in the past decades. This study aimed to establish an efficient mucoadhesive dosage form based on chitosan for the potential use in buccal application. Mercaptonicotinic acid (MNA) was covalently linked to chitosan via amide bond…
Read More...
Read More...
Cyclodextrins as multifunctional excipients
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed. The formation of the tebipenem pivoxil-β-cyclodextrin (TP-β-CD) complex resulted in changes concerning physicochemical properties of TP, which is significant for planning the development of…
Read More...
Read More...
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
The electrospinning process has gained popularity due to its ease of use, simplicity and
diverse applications. The properties of electrospun fibers can be controlled by modifying either
process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary
and…
Read More...
Read More...
Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications
Electrospun nanofibers have sparked tremendous attention in drug delivery since they can
offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred
protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun…
Read More...
Read More...
Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently
on the market or under development. Several formulation strategies including salt formation,
particle size reduction, and solid dispersion approaches have been employed with varied success.
In this review, we…
Read More...
Read More...