Browsing Category
ADM
Exploring the potential of native and modified starch and starch nanocrystals in Pickering…
Abstract
Nanocrystals derived from organic particles, such as starch, can be produced through acid or enzymatic hydrolysis reactions to serve as stabilizers in Pickering emulsions. Starch nanocrystals (SNCs) offer the advantage of providing enhanced storage stability and controlled in vitro and …
Read More...
Read More...
Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug…
Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic metabolism. The aim of this study was to explore the potential of employing Hot Melt Extrusion (HME) technology for the continuous production of Self…
Read More...
Read More...
Comparison of two self-nanoemulsifying drug delivery systems using different solidification…
In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid self-nanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its…
Read More...
Read More...
Predictions of biorelevant solubility change during dispersion and digestion of lipid-based…
Abstract
Computational approaches are increasingly explored in development of drug products, including the development of lipid-based formulations (LBFs), to assess their feasibility for achieving adequate oral absorption at an early stage. This study investigated the use of computational…
Read More...
Read More...
In Vitro Predictive Model for Intestinal Lymphatic Uptake: Exploration of Additional Enhancers and…
Abstract
Drug absorption via chylomicrons holds significant implications for both pharmacokinetics and pharmacodynamics. However, a mechanistic understanding of predicting in vivo intestinal lymphatic uptake remains largely unexplored. This study aimed to delve into the intestinal lymphatic uptake…
Read More...
Read More...
Vitafoods Geneva 2024 – with a focus on excipients
This year Vitafoods Europe opens its doors for the last time in Geneva at Palexpo.
From 14th to 16th May you can have a face-to-face chat with visitors and exhibitors again.
Pharma Excipients gives you an overview of the excipient suppliers, their booths, main topics and products in the…
Read More...
Read More...
Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Simvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility…
Read More...
Read More...
Vitamin E & TPGS Reimagined: ADM’s Novatol® and Decanox® Solutions
The sky’s the limit with ADM’s Novatol® naturally derived Decanox® mixed tocopherols and vitamin E. These powerful and plant-based antioxidants are the ideal way to help protect cells in the body from oxidative stress. Further, Novatol® vitamin E is twice as effective as synthetic vitamin E…
Read More...
Read More...
From Seed to Solution: The Unrivaled Quality of ADM Refined Sesame Oil IV-1 in Pharma
ADM Refined Sesame Oil IV-1 is a highly purified sesame oil, fully compliant with the:
"European Pharmacopoeia (0433) and United States Pharmacopeia/National Formulary (USP/NF) monographs and general notices"
intended for use in the manufacturing of pharmaceutical products.…
Read More...
Read More...
High Quality from Source to Final Product – Refined Olive Oil IV
ADMs Refined Olive Oil IV is a highly purified olive oil fully compliant with the European Pharmacopoeia (1456) and United States Pharmacopeia/National Formulary (USP/NF) monographs and general notices intended for use in the manufacturing of pharmaceutical products.
Unmatched Quality for Use as…
Read More...
Read More...