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Phase-separated polymer blends for controlled drug delivery by tuning morphology
Controlling drug release rate and providing physical and chemical stability to the active pharmaceutical ingredient are key properties of oral solid dosage forms. Here, we demonstrate a formulation strategy using phase-separated polymer blends where the morphology provides a route for tuning the…
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An Exploration of Dissolution Tests for Inhalation Aerosols
This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly…
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Oral delivery of stabilized lipid nanoparticles for nucleic acid therapeutics
Abstract
Gastrointestinal disorders originate in the gastrointestinal tract (GIT), and the therapies can benefit from direct access to the GIT achievable through the oral route. RNA molecules show great promise therapeutically but are highly susceptible to degradation and often require a carrier…
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Data-driven insights into the characteristics of liquisolid systems based on the machine learning…
Abstract
Liquisolid systems (LS) represent a formulation approach where liquid drug or its dispersion is transformed into a powder with good flowability and compactibility, leading to enhanced drug dissolution and bioavailability. Many research groups have focused on the preparation and…
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Prolonged Skin Retention of Luliconazole from SLNs Based Topical Gel Formulation Contributing to…
The development of effective therapy is necessary because the patients have to contend with long-term therapy as skin fungal infections usually relapse and are hardly treated. Despite being a potent antifungal agent, luliconazole (LCZ) has certain shortcomings such as limited skin penetration, low…
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Investigations on the Impacts of Drugs or Excipients with Different Physicochemical and Compaction…
The objective of this study was to examine the impact of the physicochemical properties of the loaded drug or excipient, the concentration of Kollidon®SR (KSR), and the mechanical characteristics of KSR compacts on their disintegration times. Using disintegration apparatus, a two-hour constraint was…
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Evaluation of different techniques for wet granulation and pelletization processes using milk as…
Abstract
The present study focused on the use of milk as a novel excipient for the manufacture of pharmaceutical dosage forms specifically designed for the pediatric population. Dairy milks with different fat contents were studied to deliver paracetamol orally. The World Health Organization…
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Managing Nitrite Impurities: A Supplier-Manufacturer Approach to Mitigate Nitrosamine Risk
N-Nitrosodimethylamine (NDMA) and other nitrosamines, are categorized as probable human carcinogens, and were first identified in drug products containing valsartan in 2018. Small, potent, alkylnitrosamines such as NDMA, commonly arise from secondary amine precursors used as starting materials,…
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Controlled dual drug release from adhesive electrospun patches for prevention and treatment of…
Abstract
Approximately one in five individuals experience alveolar osteitis (AO) following wisdom tooth extraction. AO is characterised by loss of the blood clot from the tooth extraction socket leading to infection and pain, resulting in repeated hospital visits that impose a substantial burden on…
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How sugar types and fabrication methods affect palatability in paediatric-friendly oromucosal…
Abstract
Ensuring children adhere to their prescribed medication can be challenging, particularly when a large number of medicines on the market consist of unpalatable drugs and difficult to swallow dosage forms. Sugar-based oromucosal films are easy to administer dosage forms across all age…
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