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Shield your protein of interest from challenging conditions throughout the manufacturing process and increase shelf life with Merck's high purity stabilizers. Learn how you can minimize regulatory and quality-associated risks in your biopharmaceutical manufacturing. Stabilizers – for biomolecule…
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Nanosized gel particles, so-called nanogels, have attracted substantial interest in different application fields, thanks to their controllable and three-dimensional physical structure, good mechanical properties and potential biocompatibility. Literature reports many technologies for their…
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High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding and controlling this complex process. In this paper, data fusion and multivariate modeling technique were applied to develop a…
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The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on sustained-release formulation using the Liqui-Mass technology. In this…
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In this series of webinars we will discuss the latest developments in the fields of amorphous solid dispersion (ASD) focusing on Excipient Key Attributes linked to the most popular technologies: Hot Melt Extrusion (HME), Spray Drying and their Downstream Processing. Wednesday 22 September, 3pm…
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Purpose To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients. Methods The miscibility was investigated for 350 systems applying five different oils (Labrafac ™ lipophile WL1349, Maisine®…
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Density, viscosity and surface tension of Kolliphor® ELP, the nonionic surfactant aqueous solutions were measured at temperature T = 293–318 K and at 5K interval. Steady-state fluorescence measurements have been also made using pyrene as a probe. On the basis of the obtained results, a number of…
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What is the Target Product Profile (TPP)? The Target Product Profile (TPP) describes the desired characteristics of the proposed drug product aimed at a particular disease. We consider the TPP to be a living document that may change as together we learn more about your molecule.  The TPP will…
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The value proposition for formulation scientists is:  A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers A texture optimal for patient compliance…
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Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs are usually stored at −80 °C which limits potential clinical applicability. Freeze-drying of EVs striving for long-term stable formulations is therefore studied. The most…
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