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Abstract During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery of the various other types of medications. For these to…
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Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage conditions with life-threatening complications, but no pharmacologic therapy has been approved. Drug delivery systems such as lipid nanocapsules (LNC)…
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PRESS RELEASE April 24th, 2024 Finnish startup Nordic Bioproducts Group has opened its state-of-the-art production facility in Lappeenranta, Finland. This facility, powered by the company’s proprietary AaltoCellTM Technology, is dedicated to the commercial-scale production of advanced…
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This poster was presented at the PBP World Meeting 2024 in Vienna: BACKGROUND & INTRODUCTION Topical film-forming solutions (FFSs) represent an innovative form of sustained release dermatological dosage forms. They can be applied to the skin as solutions, gels or sprays. After evaporation of…
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Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was the formulation of fast-dissolving freeze-dried sublingual…
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PRESS RELEASE April 2, 2024 Nagase Viita Co., Ltd. (Headquarters: Kita-ku, Okayama; Representative Director: Naoki Yasuba), a member of the NAGASE Group, has received the highest "Platinum" rating in a sustainability survey conducted by EcoVadis (Headquarters: France), one of the world’s most…
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Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and characterize pregelatinized starch-polyvinylpyrrolidone (PGS-PVP)…
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This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION An increasing number of APIs present stability challenges and corresponding tablets require to be formulated with protective…
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ABSTRACT The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a non-ionic surfactant. Phase solubility studies suggested…
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Lipid-based formulations (LbFs) are an extensively used approach for oral delivery of poorly soluble drug compounds in the form of lipid suspension and lipid solution. However, the high target dose and inadequate lipid solubility limit the potential of brick dust molecules to be formulated as LbFs.…
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