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Asahi Kasei
A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities
Abstract
Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a tablet compact with sufficient…
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Compaction and Structural-Mechanical Properties of Tablets as a Function of Volume Ratios of…
Introduction
Using in tablet formulations microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4 ) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural-mechanical properties of tablets.…
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Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature…
Introduction
High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the…
Abstract
Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of…
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Asahi Kasei offers pharmaceutical excipient Ceolus™ with nitrite concentration of 0.1 ppm or less
PRESS RELEASE
February 27, 2024, Asahi Kasei Corp.
Contributing to lower risk of potentially carcinogenic nitrosamine impurities in pharmaceuticals
To contribute to reducing the risk of potentially carcinogenic nitrosamine impurities in pharmaceuticals and nutritional supplements, Asahi Kasei…
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Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct…
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the…
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Quantitative analysis of wet kneading states by a novel compression test
Kneading is a process that mixes powders with liquid to produce homogeneous wet powders, with the process of kneading significantly affecting the quality and productivity of the final product. However, most kneading operations are controlled by the empirical judgment of experts. This study focused…
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Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
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Study of Compaction Tools and Parameters on Critical Quality Attributes of High Drug Load…
Minitablets are prepared using multiple die openings and multi–tip punches for greater productivity. With multiple tips on the punch barrel, the overall compaction force to be applied is commonly estimated by multiplying the desired compaction force per tip by the number of punch tips. Few…
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Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve Prescribed Medication…
Oral drug delivery is currently the gold standard in the pharmaceutical industry, regarded as the safest, most convenient and most economical method of drug delivery with the highest patient compliance . Among oral formulations, tablets and capsules are the most preferred dosage forms, but there are…
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