Biogrund

Evaluation of a new disintegrant mixture from natural resources Introduction Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are…
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Functional film coatings are a topic which considers many formulators. Therefore we gladly share this interesting overview by BIOGRUND. Definition of “Functional Film Coating”: A functional film coating has an influence on the drug release and is used to modify the release of the active…
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This year CPHI Europe opens its doors in Barcelona at Fira Barcelona Gran Via. From 24th to 26th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI. Pharma Excipients gives you an…
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Protecting moisture sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements industry. Coating the tablet core with a suitable film coating therefore plays an important role in achieving a sufficient moisture barrier. It…
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Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms (e.g., suitable for direct compression tableting). These…
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Abstract This study aimed to prototype oral dental films (ODFs) loaded with diclofenac sodium (DS) using two different grades of CompactCel® polymers through a semi-solid extrusion (SSE) bioprinter. This three-dimensional (3D) printed ODFs were developed for the treatment of toothaches with…
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Amorphous solid dispersions (ASD) are one of the most adopted technologies for improving the solubility of novel molecules. Formulation of ASDs using solvent free methods such as hot melt extrusion (HME) has been in the spotlight off-lately. However, early-stage formulation development is tricky and…
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The demand for clean label products is not stagnating, it is developing. The trend is continuing to replace artificial ingredients with natural ones (excluding artificial ingredients from back-of-pack). Our film coating system AquaPolish® offers you the possibility to give your product a nice…
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Nicardipine hydrochloride is an anti-hypertensive drug that is used off-label to treat hypertension in children. A previous oral formulation of nicardipine hydrochloride was developed using a commercial vehicle as an excipient. However, ready-to-use vehicles are prone to supply shortages, and their…
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The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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