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Biogrund
Clean label ingredients for solid oral dosage forms
In general, clean label is a consumer driven movement, demanding a return to real food and transparency through authenticity. For nutritional supplements, this means that they should contain natural, familiar, simple ingredients that are easy to recognize, understand and pronounce.
Therefore, the…
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Tunable Drug Release from Fused Deposition Modelling (FDM) 3D-Printed Tablets Fabricated Using a…
Three-dimensional (3D) printing is proving to be a pivotal technology for developing personalized dosage forms with bench to bedside feasibility. Fused deposition modelling (FDM) 3D printing has emerged as the most used technique wherein molten drug-loaded polymer filaments are deposited…
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Your visit at CPHI worldwide 2022 in Frankfurt
CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
The…
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The Stability of Probiotics in Pharmaceutical Products
Abstract
Due to their large potential applications in human diseases such as gastrointestinal disorders, immunomodulation or cholesterol reduction, probiotic products are of great interest to the pharmaceutical industry. The formulation of the pharmaceutical forms containing probiotics aims the…
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Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through…
The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just mixing different fractions of poloxamer 407 (P407) and poloxamer…
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Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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Active coating of immediate-release evogliptin tartrate to prepare fixed dose combination tablet…
This study was aimed to develop a fixed dose combination (FDC) tablet containing a low dose of evogliptin tartrate (6.87 mg) for immediate release combined with a high dose (1000 mg) of sustained-release (SR) metformin HCl appropriate for once daily dosing the treatment of type 2 diabetes. To…
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Titanium dioxide free film coating systems
European Food Safety Authority’s (EFSA) updated assessment on the safety of titanium dioxide as a food additive (published in summer 2021) concludes, that concerns about the genotoxicity of TiO2 particles cannot be excluded. As a result, the European Commission issued Commission Regulation (EU)…
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Optimization of a film coating formulation for high solid content application suitable for…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Investigating parameters that influence tablet logo bridging
The effect of a number of pan coating process parameters on the incidence of tablet logo bridging were investigated in this study. Parameters investigated included spray rate, pan speed, process air temperature, atomization and pattern air pressure. The results of the study demonstrated that logo…
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