Browsing Category
Captisol
Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles…
Abstract
Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus both Type 1 and Type 2 Diabetes mellitus. However, its intrinsic poor solubility and bioavailability is a key challenging obstacle reflecting its oral delivery. From such perspective, the purpose of…
Read More...
Read More...
Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and…
Cyclodextrins (CD) and derivatives are functional excipients that can improve the bioavailability of numerous drugs. Because of their drug solubility improving properties they are used in many pharmaceutical products. Furthermore, the stability of small molecular drugs can be improved by the…
Read More...
Read More...
Unveiling the complexation mechanism of phloretin with Sulfobutylether–β–cyclodextrin (Captisol®)…
Abstract
The incorporation of phloretin (PHL), a dihydrochalcone flavonoid, in functional foods is usually hampered by its low aqueous solubility. In this regard, we investigated the impact of complexation of PHL with sulfobutylether-β-cyclodextrin (SBE-β-CD, Captisol®) to overcome its limitation.…
Read More...
Read More...
Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated…
Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects. Nanotechnology-based formulations for vaginal administration…
Read More...
Read More...
A Review On Novel Excipients
ABSTRACT
The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of novel excipients. This review explores the types and examples…
Read More...
Read More...
Cyclodextrin: A prospective nanocarrier for the delivery of antibacterial agents against bacteria…
Abstract
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest molecules and forms host-guest complexation with non-covalent interaction. Three significant cyclodextrin kinds…
Read More...
Read More...
Improvement of the solubility and anticancer activity of 6,8-dibromochrysin by encapsulation into…
Abstract
Background
6,8-dibromochrysin (BrCN), a halogenated chrysin, possesses a profound bioactivity against dengue and Zika viruses and various types of cancer. However, the pharmaceutical applications of BrCN are limited by its poor aqueous solubility.
Methods
Molecular encapsulation…
Read More...
Read More...
Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions
Cyclodextrins (CDs) are cyclic oligosaccharides that emerged as industrial excipients in the early 1970s and are currently found in at least 130 marketed pharmaceutical products, in addition to numerous other consumer products. Although CDs have been the subject of close to 100,000 publications…
Read More...
Read More...
Inclusion complexation and liposomal encapsulation of an isoniazid hydrazone derivative in…
Tuberculosis, a predominantly pulmonary pathology, is currently the deadliest infection worldwide. Its treatment is based on combination therapy involving selected antimicrobials including Isoniazid. However, physicochemical properties of isoniazid negatively affect the clinical performance of…
Read More...
Read More...
The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review
Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of the disease, how to prevent and treat it, and to limit and hamper its global dissemination. Considering the above,…
Read More...
Read More...