Dr. Paul Lohmann

This poster was presented at the ECP 2025 in Porto Introduction Tablets are one of the most widely used oral dosage forms for oral delivery in the pharmaceutical and nutraceutical industries. If the drug dose per tablet is high and the formulation cannot ensure direct compression…
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Abstract In the present work, the application of lignin (LIG) as a bioactive additive for the preparation of drug-loaded tablets by direct compression has been studied, and its influence on the release of chlorzoxazone (CLZ) from the hydrophilic matrices has been followed. In hydrophilic matrices,…
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Abstract The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
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This poster was presented at the ECP 2025 in Porto Introduction Fig. 1. 20% drug-loaded particle microscopy before (A) and after (B) 360 minutes of thermal treatment, magnification (40x) Warfarin, a coumarin derivative, is an indirect-acting anticoagulant and a vitamin K…
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Abstract Formulation development of protein biopharmaceuticals has become increasingly challenging due to new modalities and higher desired drug substance concentrations. The constraint in drug substance supply and the need for a holistic set of analytical methods means that only a small selection…
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Abstract This study aims to investigate the effects of the relative humidity and formulation ratio on the hygroscopicity, tableting performance, and physical stability of polyols (mannitol and xylitol) as fillers in chewable tablets. To address the issues of hygroscopicity and sticking during…
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Abstract This study aims to decouple the effect of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, dwell time and strain rate were isolated from other parameters in the compaction cycle so that their independent contributions to…
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Abstract We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict and control the solid fraction, as it has a significant impact on the product quality. The solid fraction can be theoretically predicted by a first-principles model…
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Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This study aimed to enhance genistein’s solubility by developing solid dispersion (SD) and formulating them into tablets. The SDs were prepared using…
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Abstract Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low concentrations, the addition of MgSt substantially…
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